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15 Cards in this Set
- Front
- Back
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What is the mechanism of action for Papain Urea?
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The cleave any and all proteins that contain the amino acid cysteine. Urea acts to expose the cysteine which is then cleaved by papain, allowing the protein to be digested.
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What is the definition of enzymatic debridement?
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the use of topically applied chemical agents to facilitate the breakdown of necrotic or other nonviable tissue in the wound
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What are the two types of enzymatic agents?
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papain-urea and collagenase
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Why do some papain-urea products have chophyllin-copper in them?
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The cholophyll acts as a dodorizer and may also have anti-inflammatory and anti-hemagglutination properties
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T/F - Papain urea compounds degrade granulation tissue.
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True
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T/F - Papain urea compounds degrade collagen
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False - collagen does not contain cysteine
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What is the brand name of collagenase?
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Santyl
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What is the MOA of Collagenase?
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it selectively debrides denatrued collagen.
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What bacteria is the wound care product collagenase derived from?
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Clostridium
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Collagenase occurs naturally in the body as part of what group?
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MMP's (matrix metalloproteases).
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For a wound covered fully with eschar or nectrotic tissue, what is the recommended treatment with debriding agents?
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First, use papain urea to quickly remove the excessive eschar/necrosis, then switch to collagnease t selectively remove daily buildup of necrotic tissue but leave granulation tissue intact.
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What one debriding agent should be used for excessive fibrous tissue?
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Collagenase
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What one debriding agend should be used for a mixed wound bed of granulation, fibrous and necrotic tissues?
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Collagenase
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What one debriding agent should be used for excessive necrotic tissue or eschar?
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Papain-Urea
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What should you tell the pharmacy when prescribing a debriding agent?
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NO SUBSTITUTIONS
Dispense as written. |
