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20 Cards in this Set

  • Front
  • Back
what is considered acute toxicity? (number of exposures occurring over what period of time)
single or multiple exposures occurring over 1 or 2 days
what is considered chronic toxicity?
(number of exposures occurring over what period of time)
multiple exposures continuing over long period of time
what is the ability of a chemical agent to cause injury in a given situation or setting?
hazard
what is the expected frequency of the occurrence of an undesirable effect arising from exposure to a chemical or physical agent?
risk
what is the intake of a long-lasting contaminant exceeding its metabolism or excretion, leading to accumulation in tissues?
bioaccumulation
what is lead poisoning considered?
bioaccumulation
what does dose-response data represent?
risk
although the concentration of a contaminant may be undetectable in water, it may be magnified as it passes up the food chain. What is the term for this?
biomagnification
Acute toxicity with what compound results in hypoxia, psychomotor impairment, headache and tightness in the temporal area, confusion and loss of visual acuity, tachycardia, deep coma, convulsion, shock and respiratory failure?
carbon monoxide
what is the mechanism of action of acute toxicity of carbon monoxide?
CO combines reversibly with oxygen-binding sites of hemoglobin. presence of carboxyhemoglobin interferes with oxygen dissociation from remaining oxyhemoglobin reducing oxygen transfer to tissues
Which compound is a brownish irritant gas, is a deep lung irritant capable of producing pulmonary edema, and type I alveolar cells appear to be chiefly affected on acute exposure?
nitrogen oxide
Acute exposure to which compound results in irritation of the eyes and nose, coughing, mucoid or frothy sputum production, dyspnea, chest pain and pulmonary edema?
nitrogen oxide
What is the treatment for acute nitrogen oxide exposure? NO2
no treatment

usually gas exchange with oxygenation and ventilation, bronchodilators, sedatives and antibiotics
Exposure to which compound results in upper respiratory tract irritation, shallow rapid breathing and decrease in pulmonary compliance?
ozone
which populations are at risk for exposure to ozone?
children that play outdoors, people with lung disease, elderly, healthy adults that exert themselves outdoors, athletes exercising outdoors
What does benzene primarily affect?
bone marrow damage, induces chromosomal aberrations
What does benzene cause?
depression of the CNS, bone marrow injury, aplastic anemia, leucopenia, pancytopenia, thrombocytopenia, acute myeloid leukemia
which compounds are generated from combustion?
carbon monoxide, nitrogen oxide, sulfur dioxide
which compound results in formation of sulfurous acid on contact with moist membranes, and 90% is absorbed in the upper respiratory tract?
sulfur dioxide
Which compound has toxic effects of bronchial constriction, irritation of the eyes nose and throat, delayed pulmonary edema after severe exposure, chronic exposure associated with aggravation of chronic cardiopulmonary disease?
sulfur dioxide