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5 Cards in this Set
- Front
- Back
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What is effected by the complications of diabetes?
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Kidney, eyes, nerves, heart, vascular, stroke.
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What role does AGE have microvascular complaints?
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Glucose becomes attached to proteins eventually this becomes permanent forming advanced glycation end-products.
These acuminate in relation to [glucose] and don't function normally, they cause reactive oxygen species and promote extracellular matrix accumulation. |
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Why may anti-AGE drugs not work?
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The high quantity of AGE drugs in the diet (from cooking processes) may swap the action of the drugs.
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What is the sorbitol pathway and how does it contribute to the complications of diabetes?
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In excess glucose can be metabolised to sorbitol by aldose reductase. This utilise NADPH and NAD+. The reduction of glutathione. This is important for reducing oxygen reactive species. therefor a lack of it can lead to cell damage.
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Why are anti-sorbitole drugs disappointing?
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They should work as we know aldose reductase can be inhibited. But it seems there must be many pathways involved as blocking this one has been disappointing.
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