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6 Cards in this Set
- Front
- Back
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Regulation of Lipolysis |
promote: Leptin LPL Phosphorylated perilipin Beta adrenergic receptors catecholamines TNFa and IL6 (which impede IRS)
inhibit: insulin adiponectin potentiates insulin alpha-2-adrenergic receptorss perilipin protects adipocytes and promotes storage |
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Liproteins, function and respective apolipoproteins necessary for action |
CM - deliver dietary TG and cholesterol from intestine to tissue and liver
VLDL - synthesized by the liver, deliver plasma TG to tissue Apoproteins = C2, B100
LDL - deliver cholesterol to tissues, derived from IDL (remnant) by liver Apoproteins = B100 |
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Lipid Profile |
measures: Tc HDLc total TG
calculate: LDL = Tc - [(TG/2.2) + HDLc] ** if TG <4.5 non-HDL = Tc - HDLc VLDL ~ TG/2.2 Tc:HDL = Tc/HDLc |
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Primary Hyperlipidemia based on lipid profile |
^TG >10: Chylomicronemia (LPL or C2 deficiency) 2-10: Familial Combined (^apoB)
^BOTH C>TG =Familial Combined C=TG = Dys-B-lipoproteinemia (ApoE2 mut.)
^Cholesterol = Familial Hypercholesterolemia 1- LDLR mut; 2- B100 mutation; 3- PCSK9 GOF
low HDL |
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Chylomicronemia |
LPL or apoC2 deficiency results in increased CM in the blood
Presentation: acute/recurrent pancreatitis, eruptive xanthoma, hepatosplenomegaly, lipemia retinalis
Lab: TG>10, lipemic serum
Tx: FIBRATE |
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Dys-Beta-Lipoproteinemia |
Apo-E2 mutation = less affinity for receptor CM/VLDL |
