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26 Cards in this Set
- Front
- Back
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Fludrocortisone |
Minoralocorticoids Use after adrenalectomy or adrenal insufficiency Orally Cause- hypokalemia |
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Spironolactactone |
Competitive antagonist at aldosterone receptors in the DCT increase K Decrease Na Cause- hyperkalaemia Hyponatremia Gynacomastia Irregular menstrual cycle |
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Glucocorticoids ADR |
Orophargeal carcinoma Purple stria |
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MOA glucocorticoids |
Inhibit vitamin D mediated Ca absorption Hypocalcemia Secondary hyperparathyroidism |
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Corticosteroids |
Prednisone- orally pro drug must be converted to prednisolon Dexamethasone- long Betamethasone- long |
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Amiloride |
Increase potassium and calcium |
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Levothyroxine |
Orally Choice of choice Use for hypothyroidism ARD- tachycardia Heat intolerance Tremors Prevent mental retardation in children with thyroid deficiency |
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Liothyronine |
T3 More potent than T4 Treat myxedema with levothyroxin Mote expensive than T4 |
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5'deodinase |
T4-T3 |
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5 deodinase |
T4- inactive T3 |
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Propylthiouracil PTU |
Inhibit oxidation iodination coupling and peripheral conversion of T4-T3 of thyroid synthesis Orally Crosses placenta Better used in pregnancy because less free drugs cross the placenta Short half life |
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Methimazole |
More active the PTU More potent in oxidation but do not inhibit coupling or peripheral conversion of T4-T3 Orally Carbimazole-methimazole Crosses placenta |
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Thioamides |
Use for hyperthyroidism Thyroid storm Preparation for thyroid surgery |
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Thioamides ADR |
hypoprothrobinemia Agranulocutosis Vasculitis |
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Iodides |
Inhibit iodine metabolism Angioedema Burning of the mouth and throat Crosses placenta cause gioter Hyperthyroidism Decreases size and vascularity of hyperplastic gland |
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Radioiodine |
Hyperthyroidism Thyroid cancer Incorporate in thyroglobulin Half life 10days Not expensive and pain free treatment |
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Lithoum |
Use for hyperthyroidism Cause hypothyroidism Inhibit thyroid hormoned |
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Amidorarone |
Use for hypothyroidism Resemble thyroid hormone Can cause hyperthyroidism |
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Sulfonylurase |
Type 2 diabetes Enhance insulin release from pancreatic beta cells 2nd generation more potent Orally |
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Glargine |
Long acting insulin |
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Lispro |
Short acting insulin |
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Drug interaction of insulin |
Increase hypoglycemia Alcohol- inhibit gluconeogenesis Salicylates- increase beta cell sensitivity to glucose and enhance insulin secretion Beta antagonist |
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Half life of thyroid home |
T3- 1day T4- 6days |
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Drug interaction of Thyroid |
Cholestyramine Sucralfate Beta blockers Oestrogen |
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Lugol's solution |
Mixture of iodine and potassium iodide |
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Coritiocosterides in thyroid |
Inhibit 5'deiodinase thus no conversion of T4-T3 |
