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5 Cards in this Set
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Function of oxyphils:
urinary _____ is a good indicator of PTH levels. 80-85% of primary hyperthyroidism is due to what? Cancer that notably causes PTHrP release: |
unknown
cAMP parathyroid adenoma squamous lung cancer |
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Lesions in bone due to hyperPTH activity:
First usual symptom of hypercalcemia? Characteristic labs of hyperPTH? |
osteitis fibrosa cystica
von Recklinghausen's disease brown tumors fatigue high Ca, low P, high urine Ca and cAMP |
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Gene implicated in primary parathyroid adenoma:
What scan can localize parathyroid glands? What does the scan light up? Parathyroid hyperplasia should make you suspicious of: |
PRAD-1 (bcl-1)
sestamibi T-99 mitochondria one of the MEN syndromes |
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What is secondary hyperparathyroidism?
Mutation in familial hypocalciuric hypercalcemia: Most common cause of hypoPTH: |
parathyroid hyperplasia due to hypocalcemia, hyperphosphatemia, PTH resistance; usually from renal failure
CaSR - body thinks low Ca, so increases PTh secretion iatrogenic - thyroid surgery |
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Common causes of hypercalcemia:
CHIMPANZEES: |
Ca (milk-alkali)
HyperPTH, hyperthyroid Iatrogenic (TZ's) Multiple myeloma Paget's Addison's Neoplasm Zollinger-Ellison Excess vit A, vit D Sarcoiosis |
