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12 Cards in this Set
- Front
- Back
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Primary endocrine mechanisms that maintain BP
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Catecholamines, Renin-Angiotensin-Aldosterone
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RAAS key pts
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Angio II has direct effects on vascular tone; Aldo has indirect effects on BV
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Primary Mineralocoriticoid Excess
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Rare cause of HTN. See Na retention + plasma volume expansion; hypokalemia due to excess K+ excretion. **must be distinguished from essential HTN pts taking diuretics
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factors that increase renin
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Na depletion, upright posture, hypovolemia,
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factors that decrease renin
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salt loading, supine posture, high K, high Ca, ADH, ANF, Aldo
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factors that increase aldo
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high K, ACTH, Angio II
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factors that decrease Aldo
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ANF, increased age
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Promary hyperaldosteronism
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High aldo, high Na, K+ loss, low renin, low angio
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Dx of pt w/ HTN and Hypokalemia
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Check plasma renin activity (PRA) and plasma aldo concentration (PAC)
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high PAC/PRA; PAC:PRA ratio =10
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likely secondary hyperaldosteronism
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high PAC/low PRAPAC:PRA ratio 20+
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likely primary aldosteronism
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low PRA/PAC
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think cushing's liddle's congenital adrenal hyperplasia
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