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18 Cards in this Set
- Front
- Back
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Glyburide, Glipizide, Glimepiride
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Sulfonylureas
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Glyburide
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t1/2= 1-2hrs, but 24 hr action
Best for elderly due to the small half life. Easy to use package. |
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Glipizide
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t1/2= 2-4 hrs
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Contraindications for Sulfonylurea Use
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1.DKA
2.Diabetic coma |
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Caution when using Sulfonylureas
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1.Renal/Hepatic Dz
2.HYPOGLYCEMIA 3.Metabolic Stress |
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BLACK BOX on Sulfonylureas
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May increase CV mortality (mainly 1st generations)
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When do pts take sulfonylureas?
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30 mins b/f meals
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Meglitinide and Nateglinide
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Secretagogous (other than sulfonylureas)
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When should pts take Meglitinide and Nateglinide
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15 mins bf meal... TID...short acting
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SE of 'other secretagogous'
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Hypoglycemia
GI disturbance Arthralgia Weight gain |
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Meglitinide
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t1/2= <1hr...3hr action
*Work through Cyt P450 pathway, so competes with macrolides and antifungals for metabolism* |
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Meglitinide and Nateglinide Contraindication
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T1DM
DKA |
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Nateglinide
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t1/2= 1.5hrs
*Work through Cyt P450 pathway* |
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Metformin
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Can be used in 10yo and up. DOES NOT cause hypoglycemia. Works by decreasing gluconeogensis and absorption of glucose from GI. Increases glucose intake by skeletal muscle.
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Metformin T Max
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4-8hrs
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SE of metformin
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GI disturbance
Weight loss Metallic taste in mouth |
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CI of metformin
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Renal dysfnx
Abnormal CrCl CHF requiring meds Metabolic acidosis |
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Metformin Black Box
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Lactic Acidosis: Monitor creatinine and GFR. Initial presenting symptom is Abdominal Pain.
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