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30 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Lispro
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Rapid Acting Insulin
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Aspart
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Rapid acting insulin
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regular insulin
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rapid acting insulin
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NPH
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intermediate acting insulin
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glargine
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intermediate acting insulin
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detemir
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intermediate acting insulin
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Insulin (Action...)
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Liver: increase glucose stored as glycogen
muscle: increase glycogen and protein synthesis, K+ uptake Fat: aids triglyceride storage |
Use: DMI, DMII, gestational diabetes, life threatening hyperkalemia, stress induced hyperglycemia
Toxicities: hyopglycemia, hypersensitivity reaction (very rare) |
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tolbutamide
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first generation sulfonylurea
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chloropropamide
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first generation sulfonylurea
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glyburide
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second generation sulfonylurea
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glimepiride
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second generation sulfonylurea
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glipizide
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second generation sulfonylurea
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sulfonylurea (Action...)
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close K+ channel in beta cell membrane so cell depolarizes causing insulin release by allowing calcium to enter
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Use: stimulate release of endogenous insulin in type II DM
Toxicities: first gen- disulfram like effects second gen- hypoglycemia |
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metformin
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increase glycolysis and peripheral glucose uptake, decrease gluconeogenesis
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Use: can be given to type I or type II
Toxicity: lactic acidosis, contraindicated in renal failure |
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pioglitazone
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glitazone/ thiazolidinediones
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rosiglitazone
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glitazone/ thiazolidinediones
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glitazone/ thiazolidinediones
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increase insulin sensitivity in peripheral tissue by binding to PPAR gamma nucear transcription regulator
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Use: monotherapy or in combination
Toxicity: weight gain, edema, hepatotoxicity, cardiotoxicity |
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acarbose
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alpha glucosidae inhibitor
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alpha glucosidase inhibitor
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inhibit bursh border alpha glucosidases so sugar hydrolysis and glucose absorption are delayed. leads to a decrease in post-prandial hyperglycemia
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Use: monotherapy in DM II or combination
Toxicities: GI disturbances |
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exantide
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GLP-1 analogue that increases insulin and decreases glucagon
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Use: type II DM
toxicity: nausea, vomiting, pancreatitis |
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Propylthiourcail (PTU)
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inhibitors organification of iodide and coupling of thyroid hornome synthesis, decreases peripheral conversion of T4 to T3
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Use: hyperthyroidism
Toxicity: skin rash, agranulocytosis (rarely) aplastic anemia, |
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methimazole
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inhibitors organification of iodide and coupling of thyroid hornome synthesis
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Use: hyperthyroidism
Toxicity: skin rash, agranulocytosis (rarely) aplastic anemia, possible teratogen |
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Levothyroxine
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thyroxine replacement
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Use: hypothyroidism, myxedema
Toxicity: tachycardia, heat intolerance, tremors, arrhythmias |
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triiodothyronine
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thyroxine replacement
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Use: hypothyroidism, myxedema
Toxicity: tachycardia, heat intolerance, tremors, arrhythmias |
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GH
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GH deficiency, Turner's syndrome(increase height), Prader-Willi syndrome (decrease body fat, increase muscle ration)
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Somatostatin
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acromegaly, carcinoid, gastrinoma, glucagonoma
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Demeclocycline
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ADH antagonist (a tetracycline)
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'Use: SIADH
Toxicity: nephrogenic DI, photosensitivity, abnormalities of bone and teeth |
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Terlipressin
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Receptor V1 agonist
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Esophageal Varices
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Desmopressin
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Recptor V2 agonist
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1.Treat Central diabetes insipidus
2.increase VIII and vWF |
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glucocorticoids
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decrease the production of leukotrienes and prostaglandins by inhibiting PLA2 and expression of cox 2
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Use: Addison's, inflammation, immune suppression, asthma
Toxicity: iatrogenic Cushing's; adrenal insufficiency when drug is stopped |
