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30 Cards in this Set

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Treatment of pheochromocytoma?

class?
phenoxybenzamine

alpha blocker
Treatment of SIADH?
demeclocycline
Blockers of 5'-deiodinase (3)
propranolol
glucocorticoids
propylthiouracil
What is a goitrogen?
a chemical that causes goiter (i.e. a hypertrophied thyroid gland)
Goitrogens:

inhibitors of iodine transport (2)

inhibitors of binding/coupling (2)
thiocyanate
perchlorate

propylthiouracil
methimazole
Calcitonin can be used therapeutically for.... (2)
osteoporosis
Paget's

and anything else involved with hypercalcemia
Important treatment for hyperkalemia
Give insulin
Treatment for Conn's syndrome
spironolactone
Treatment of diabetes insipidus:

central (1)

nephrogenic (3)
desmopressin

hydrochlorothiazide
indomethacin
amiloride
Treatment of carcinoid syndrome

whate else is this agent used to treat (2)
octreotide

intractable diarrhea
GI bleeding
Another name for GnRH
gonadorelin
Leuprolide indications:

pulsatile use (1)

continuous use (3)
infertility
(acts as a GnRH agonist)

prostrate cancer
uterine fibroids
endometriosus
(acts as a GnRH antagonist)
Bromocriptine MOA?

use? (2)
dopamine receptor agonist

hyperprolactinemia
acromegaly
Oxcytocin use? (2)
induce labor
decrease postpartum bleeding

dinoprostone is also used for the former
name two uterine relaxants and their MOA
ritodrine
terbutaline

B2 agonists
What are menotropins and what are they used for?
partially degraded FSH and LH

used to induce follicle maturation in infertile women
ACTH analog?
cosyntropin
Name three agents used to treat hypothyroidism
levothyroxine (T4)
Liothyronine
Liotrix (combo of the above two)
Iodine use? (2)
pre-ope shrink of thyroid
thyroid storm
Propylthiouracil and methimazile MOA?

use?

which one can inhibit peripheral conversion of T4 to T3?
inhibit peroxidase enzymes

hyperthyroidism

propylthiouracil
most serious SE of propylthiouracil?

why is it preferred in pregnancy and why?
agranulocytosis

PTU is more protien bond and has less chance to cross placenta or milk to induce hypothyroidim
Treatment for severe tetany as well as severe hyperkalemia
calcium gluconate
Disphosphonates:

Name two?

MOA?

use?
etidronate disodium
pamidronate disodium

bind hydroxyapatie crystals and stalls bone resorption

Pagets
osteoporosis and others
Treatment for bronchial asthma
beclmethasone
ketoconazole MOA?

use? (2)
inhibits steroid synthesis

polycystic ovarian syndrome
hirsutism
Name 4 sulfonylureas?

MOA?

use?
tolbutamide chlopropamide
glyburide glypizide

stimulate B cells to secrete insulin

NIDDM
SE of 1st generation sulfonylureas (tolbutamide, chlorpropamide)
disulfiram like effects
Metformin use?

SE?
anti-hyperglycemic
(unknowm mechanism)

lactic acidosis
acarbose and miglitol MOA?
a-glucosidase inhibitors in brush border decreases glucose absorption
Glitazones: (pioglitazone, rosiglitazone, troglitazone)

MOA?
increase the sensitivity of tissues to insulin by binding PPARS