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17 Cards in this Set

  • Front
  • Back
Thyroid functions
maintains metabolic homeostasis
normal development
regulates myocardial gene expression
stimulates synthesis of proteins and increased cellular demand for oxygen
Thyroid peroxidase
enzyme that catalyzes iodine/globulin into T4 and T3
5' Deiodinase enzyme catalyzes
T4 to T3 in cells
Signs of hypothyroidism
Lethargy
Weight gain
Alopecia
Cold intolerance
Bradycardia
Hypercholesterolemia
Signs of hyperthyroidism
Weight loss
Polyphagia
Hyperactivity
Tachycardia
Vomiting
Thyroid hormones
L-thyroxine T4
L-triiodothyronine
L-thyroxine
more physiological (in body T4 in feedback mechanism)
More consistent bioavailability
L-triiodothyronine is used when
unresponsive to T4
Anti-thyroid meds
Methimazole
Radioactive Iodine
Methimazole
Blocks incorporation of iodine into thyroglobulin
prevents coupling of iodotyrosil groups
inhibits thyroid peroxidase
Radioactive Iodine
selectively destroys thyroid tissue after take up by thyroid gland
emits gamma and Beta particles, given orally
Thyroid drug interactions
Glucocorticoids - decreases TSH release, interferes with 5'deiodinase
Phenobarbital - increases metabolism of T3/T4 by inducing P450
NSAIDS - interfere with binding of T3/T4 to serum proteins
T3 =
DIT + MIT
T4 =
2DIT
T4 is converted to T3 by
deiodination
T3 is _______ than T4
more potent
T131 requires
hospitalization for 14 days