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17 Cards in this Set
- Front
- Back
Thyroid functions
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maintains metabolic homeostasis
normal development regulates myocardial gene expression stimulates synthesis of proteins and increased cellular demand for oxygen |
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Thyroid peroxidase
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enzyme that catalyzes iodine/globulin into T4 and T3
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5' Deiodinase enzyme catalyzes
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T4 to T3 in cells
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Signs of hypothyroidism
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Lethargy
Weight gain Alopecia Cold intolerance Bradycardia Hypercholesterolemia |
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Signs of hyperthyroidism
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Weight loss
Polyphagia Hyperactivity Tachycardia Vomiting |
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Thyroid hormones
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L-thyroxine T4
L-triiodothyronine |
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L-thyroxine
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more physiological (in body T4 in feedback mechanism)
More consistent bioavailability |
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L-triiodothyronine is used when
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unresponsive to T4
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Anti-thyroid meds
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Methimazole
Radioactive Iodine |
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Methimazole
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Blocks incorporation of iodine into thyroglobulin
prevents coupling of iodotyrosil groups inhibits thyroid peroxidase |
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Radioactive Iodine
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selectively destroys thyroid tissue after take up by thyroid gland
emits gamma and Beta particles, given orally |
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Thyroid drug interactions
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Glucocorticoids - decreases TSH release, interferes with 5'deiodinase
Phenobarbital - increases metabolism of T3/T4 by inducing P450 NSAIDS - interfere with binding of T3/T4 to serum proteins |
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T3 =
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DIT + MIT
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T4 =
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2DIT
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T4 is converted to T3 by
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deiodination
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T3 is _______ than T4
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more potent
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T131 requires
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hospitalization for 14 days
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