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57 Cards in this Set
- Front
- Back
amines and amino acid hormones
|
dopamine
NE/EPI water solube |
|
peptides polypetide hormones
|
ADH
Inculin glucagon prolactin rough ER |
|
steriodal hormone
|
testost
estorgen glucocort lipid soluable must be transported by protein smooth ER |
|
when body needs calcium, _______ is released
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parathyroid
|
|
unbound hormones
|
shorter half life
peptides |
|
bound hormones
|
longer half life
steroids |
|
steroids are stored actively/inactively
|
inactively
|
|
catecholamines are inactivated by what enzyme
|
MAO/COMT
|
|
thyroid is a ______ soluble hormone.
|
lipid
|
|
anti pituitary hormones
|
TSH
ACTH LH FSH GH PROL |
|
posterior pituitary hormones
|
antidiuretic hormone
oxytocin |
|
what is the route of hormone control
|
hypothalamus>AP>target organ
|
|
positive feedback
|
rising hormone levels cause release of another hormone
estradiole |
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suspect gland hypofunction. what to do?
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give stimulator. if gland doesnt increase production. gland truly hypofunction
|
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primary endocrine disorder
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actual gland problem
|
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secondary endocrine disorder
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pituitary gland problem
|
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tertiary endocrine disorder
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hypothalamus gland problem
|
|
functional pituitary tumors secrete/dont secrete hormones
|
secrete
|
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what hormone is most effected by hypopituitarism?
|
acth
|
|
when should you assess pituitary function?
|
8am
|
|
3 things GH does
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growth
protein synth carb metab |
|
how does GH effect bone, organs, muscle, fat, carb metab?
|
bone- ^ linear growth
organ- ^ size/ function muscle- ^ lean muscle mass glucose- ^ BGL fat - decreases |
|
GH as a drug. AE
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hyperglycemia
paresthesias arthralgia/myalgia peripheral edema |
|
GH excess in children
|
Giantism
tumor brain tall |
|
GH excess in adults
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acromegaly
tumor brain insidious |
|
acromegly treatment
|
sx
rad somatostatin |
|
acromegly clinical manifest
|
sweaty/oily
heat intolerance weight gain all organs effect long hands |
|
somatostatin
|
treats acromeg
GH antagonist AE: GI/Gallstone |
|
T3 active/inactive
|
active
|
|
T4 active/inactive
|
inactive
|
|
which T has a longer half life?
|
4
|
|
thyroid regulation is positive/negative feedback
|
negative
|
|
primary hypothyroidism what would the TSH/T3, T4
|
TSH increase
T3 T4 decrease the gland is not working so T3/T4 are decreased and TSH ^ to try and make up for it |
|
what is congenital hypothyroidism called?
|
cretinism
|
|
what is aquired hypothyroidism called?
|
myxedema
|
|
hypothyroidism clinical features
|
pale
edematous expressionless cold dry skin brittle coarse hair lethargy fatigue cold intolerance decreased HR |
|
levothyroxine
|
identical T4
protein bound metabolized by liver excreted feces |
|
tsh level
|
0.5 - 5.0 normal
|
|
levothyroxine drug interact
|
^these:
coumadin catetcholamines dig |
|
drugs that accelerate metab levothy
|
phenytoin
caraba rifam pheno setraline |
|
drugs that decrease absorb levothy
|
ca+
antacid iron |
|
if woman taking levothy, what happens with prego?
|
increase beggining 4 - 8 wk of gestation
|
|
avoid what common food chemical while taking levothy
|
iodine
|
|
hyperthyroidism is aka
|
graves disease
|
|
graves disease precipitating factors
|
toxic adenoma
toxic goiter thyroiditis too much iodine too much TSH |
|
graves clinical features
|
nervous
palpitations tachycar healt intolerance sweaty treamors appetite change weight loss frequent bowel movement menstrual irregularities |
|
tx options graves
|
rad iodine
anti thy drug sx |
|
PTU
|
drug for graves
suppress T4/T3 liver urine/bile/milk |
|
adverse effects/side effects PTU
|
AE
agranulocytosis hypothyroidism SE: rash, nausea, arthralgia, headache, dizziness, paresthesias |
|
PTU drug interactions
|
^
heparin lithium radiation |
|
diabetes insipidus
|
deficiency of ADH
poly dipsia/uria loss of water w/out Na+ hypernatremia |
|
diabetes insipidus
|
desmopressin
|
|
SIADH clin manif
|
hypotonicity
hyponatremia urine osmolality high low HCT/BUN levels |
|
SIADH s/s
|
weakness
muscle cramps n/v orthopnea fatigue anorexia lethargy seizure coma |
|
SIADH what is it?
|
too much ADH
not peeing enough |
|
SIADH tx
|
fluid restriction
furosimide conivaptan (adh antagonist) |
|
hypoparathyroidism manifest
|
lethargy
muscle spasm tingling in fingers numbness/cramps seizures visual changes |