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8 Cards in this Set
- Front
- Back
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What is a first order feedback loop?
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The hormone secreting cell senses a need, secretes the hormone that will meet the need, sense that the need has been met, and then cease secreting.
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What is a long feedback loop?
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Target gland hormone feeds back negatively to the anterior pituitary and to the hypothalamus.
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What is a short feedback loop?
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Pituitary trophic hormone feeds back negatively to the hypothalamus.
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What is an ultrashort feedback loop?
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Hypothalamic releasing hormone feeds back negatively to the hypothalamus itself.
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What is a radioimmunoassay?
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Ab is incubated with a specific radiolabelled hormone. Patient's plasma is then added and the amount of radiolabelled hormone that is displaced by the original is a measure of how much hormone exists in the plasma.
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What is an ELISA for hormone measurement?
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A well coated with Ab1 is specific to the hormone. The patient's serum is then added to the well and washed. Ab2 is later added, which is specific to a different epitope of the same hormone. Ab3, covalently attached to a radiolabeled enzyme and specific for the Ab2 Fc, is finally added. The amoutn fo fluorescence indicates presence of hormone.
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When is a stimulation test used and how is it done?
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To study hypofunction of a gland. A hormone is injected that is trophic for the gland being studied.
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When is a suppression test used and how is it done?
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To study hyperfunction of a gland. Inject a molecule that feeds back negatively for the gland and see if it gets suppressed at all.
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