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23 Cards in this Set

  • Front
  • Back
What are the layers of the cortex of the adrenal? what is produced by each
Glomerulosa: Minearlcorticoids (CYP11B2, NO CYP 17)

Fasiculata: Glucocorticoids

Reticularis: Androgens
What is produced by the adrenal medulla?
Catecholamines (Epi/NE)
What is the trophic support for the adrenal gland (what gives it the ability to be maintained)
ACTH
Starting with cholesterol, please go over steroid synthesis
What is responsible for the zona glomerulosa releasing its product?
Angiotensin II

(remember the glomerulosa releases aldosterone)
ACTH is a product of what?
POMC
What is the action of ACTH when it binds to fasciculata cells? (name the receptor too)
ACTH binds to melanocortin-2 receptor in fasciculata cells
GPCR - - cAMP
acute: increase in StAR; chronic: increase in steroidogenic enzyme
What effect does cortisol have on the pituitary with respect to CRH?
(-) synthesis of CRH receptor
(-) synthesis of ACTH
What inhibits the secretion of glucocorticoids? how does it accomplish this?
ANP

(-) StAR
increased appetitie, decreased linear growth, HTN, peptic ulcerations, and decreased bone mass are all results of what?
increased glucocorticoids
What is the primary stimulator of the secretion of mineralocorticoids? Inhibited by?
Stimulator: Ang II (activates CYP11B2)

Inhibitor: ANP

remember: mineralocorticoids-->aldosterone
what is responsible for turning active glucocorticoid to inactive?
the kidney

Kidney contains 11β hydroxysteroid dehydrogenase type 2
Are adrenal androgens an important contributor of circulating androgens in men or women?
WOMEN
What cells store catecholamines in the adrenal medulla?
Chromaffin cell
what 3 things can lead to catecholamine secretion?
ACTH

Cortisol

Sympathetic stimulation
What are secreted with catecholamines from the chromaffin cell? what is their role?
Chromogranin catabolic products

amino terminal (vasostatin) vasoinhibitory effects on bv

peptide fragment, catestatin, (-) nicotinic acetylcholine
receptor, limiting further catecholamine secretion
The expression of CYP_____ is restricted to the glomerulosa layer .

results in this being the site of aldosterone production.
CYP11B2
Ang II and K+ stimulate the zona glmomerulosa to release _____
Aldosterone
ACTH stimulates the Zona Fasiculata (mostly) to release _____
Cortisol
At the hypothalamus, cortisol ___ the release of CRH
inhibits
Glucocorticoids work via _____ receptors
Intracellular, Nuclear
______ is the primary regulator of ACTH
Cortisol
Excess aldosterone leads to ____
HTN