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23 Cards in this Set
- Front
- Back
What are the layers of the cortex of the adrenal? what is produced by each
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Glomerulosa: Minearlcorticoids (CYP11B2, NO CYP 17)
Fasiculata: Glucocorticoids Reticularis: Androgens |
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What is produced by the adrenal medulla?
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Catecholamines (Epi/NE)
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What is the trophic support for the adrenal gland (what gives it the ability to be maintained)
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ACTH
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Starting with cholesterol, please go over steroid synthesis
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What is responsible for the zona glomerulosa releasing its product?
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Angiotensin II
(remember the glomerulosa releases aldosterone) |
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ACTH is a product of what?
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POMC
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What is the action of ACTH when it binds to fasciculata cells? (name the receptor too)
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ACTH binds to melanocortin-2 receptor in fasciculata cells
GPCR - - cAMP acute: increase in StAR; chronic: increase in steroidogenic enzyme |
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What effect does cortisol have on the pituitary with respect to CRH?
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(-) synthesis of CRH receptor
(-) synthesis of ACTH |
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What inhibits the secretion of glucocorticoids? how does it accomplish this?
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ANP
(-) StAR |
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increased appetitie, decreased linear growth, HTN, peptic ulcerations, and decreased bone mass are all results of what?
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increased glucocorticoids
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What is the primary stimulator of the secretion of mineralocorticoids? Inhibited by?
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Stimulator: Ang II (activates CYP11B2)
Inhibitor: ANP remember: mineralocorticoids-->aldosterone |
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what is responsible for turning active glucocorticoid to inactive?
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the kidney
Kidney contains 11β hydroxysteroid dehydrogenase type 2 |
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Are adrenal androgens an important contributor of circulating androgens in men or women?
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WOMEN
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What cells store catecholamines in the adrenal medulla?
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Chromaffin cell
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what 3 things can lead to catecholamine secretion?
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ACTH
Cortisol Sympathetic stimulation |
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What are secreted with catecholamines from the chromaffin cell? what is their role?
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Chromogranin catabolic products
amino terminal (vasostatin) vasoinhibitory effects on bv peptide fragment, catestatin, (-) nicotinic acetylcholine receptor, limiting further catecholamine secretion |
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The expression of CYP_____ is restricted to the glomerulosa layer .
results in this being the site of aldosterone production. |
CYP11B2
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Ang II and K+ stimulate the zona glmomerulosa to release _____
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Aldosterone
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ACTH stimulates the Zona Fasiculata (mostly) to release _____
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Cortisol
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At the hypothalamus, cortisol ___ the release of CRH
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inhibits
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Glucocorticoids work via _____ receptors
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Intracellular, Nuclear
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______ is the primary regulator of ACTH
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Cortisol
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Excess aldosterone leads to ____
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HTN
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