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21 Cards in this Set
- Front
- Back
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Describe the pattern of GH secretion
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pulsatile secretion
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what is the purpose of the binding proteins of the GH
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extends the half life
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where are GH receptors
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liver, m, adipose
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what pathway does GH stimulate
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JAK/STAT pathway
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what is the primary function of GH
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growth, metabolism
Increased lipolysis and lipid oxidation, which leads to mobilization of stored triglyceride Stimulation of protein synthesis Antagonism of insulin action Stimulates linear growth (directly and indirectly via IGF-1) |
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what regulates the overproduction/underproduction of GH
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GH and IGF-1 (and somatostatin and GHRH)
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need to know the feed back loops
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draw it
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peptide hormones that are insulin like growth factors
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IGF-1 and IGF-II
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how does IGF-1 and II work on the cell membrane
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Work via plasma mbrane receptors: IGFR1 & IGFR2
IGFR1 – tyrosine kinase IGFR2 - ? signalling |
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what hormone has the follwoing main effects:
growth protein synthesis utilization of glucose increases glomerular filtration |
IGF-1
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the liver grows IGF-1 after stimulation from
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GH
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What do you find attached to IGF-1?
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IGFBP-3 (bound to proteins in the circulation) know this binding protein
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what is the purpose of IGFBP-3
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transport IGF-1 and increase half life
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relate insulin and IGF receptors
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there is a receptor that can accept both IGF-1 and II and insulin, so if there is an increase in insulin, cross talk can occur when it binds to the IGF receptor
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IGF-1 receptor
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Type I receptor: IGF-1 receptor
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Insulin receptor
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IR-A/IR-B: Insulin receptor
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Hybrid: IGF-insulin receptor significance?
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Hybrid receptors that allow cross talk between insulin and IGF-I when their levels are high because although they have specific affinity for a certain hormone, they can bind insulin or IGF-1 at high levels
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what is the function of ALS for IGF-1
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ALS: acid labile subunit; stabilizes IGF-BP3 to increase ½ life;
(+) by GH |
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relate insulin and IGF-1
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they have antagonistics mechanisms (see diagram in lecture) and complementary functions depending on where IGF-1 is working
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Inhibits release of
GH, PRL, and TSH from pituitary Insulin and glucagon from pancreas Secretions from enteroendocrine cells |
somatostatin
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what are the receptors for somatostatin
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SSRT 1, 2, ,3 ,4 ,5 - they are second messanger pathways which allow for different affects depending what follows after the SSRT
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