Endo-Ics-Ca++ And Bone Metabolism

Front 1

PTH
-stim by what?
-actions

Back 1

*stim by low Ca++

Actions:
1. Bone: incr Ca++ & PO4 resorption
2. GI: incr Ca++ abs
3. Kidney: incr Ca++ abs;
decr phosphate abs;
converts 25(OH)D==>1,25(OH)2 D

Front 2

1,25(OH)2 D
-stim by what?
-actions?

Back 2

Kidney converts 25(OH)D==>1,25(OH)2 D in response to:

1. low serum Ca++
2. low serum phosphorus

Actions:
1. Bone: incr Ca++ & PO4 resorp
2. GI: incr Ca++ & PO4 abs

Front 3

Calcitonin

Back 3

1. Kidney: ↑ Ca++ excretion
2. Bone: ↓ Ca++ release
3. GI: ↓ Ca++ abs

Front 4

et of Hypercalcemia

Back 4

1. MCC=Hyper-PTH
2. Malignancy
3. FHH=Familial Hypocalinuric Hypercalcemia)

distinguish b/w them b/c FHH has very little Ca++ in urine)

4. MEN 1, 2

Front 5

hypocalcemia
-Sx?
-et?

Back 5

Sx:
tetany
hypotension
bradycardia
EKG changes:
-prolonged QT, ST
-abnl T wave

Et:
-hypo-PTH
-PTH resistance="Pseudohypoparathyrodism"
-Vit D def

Front 6

Pseudohypoparathyroidism

Back 6

=PTH resistance

-causes hypocalcemia