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27 Cards in this Set
- Front
- Back
At what week do migration of germ cells migrate into gonadal ridges?
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5 weeks
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True or False
A full set of essential genes from both X chromosomes are required for full formation of the ovary with retention of primordial follicles. |
True
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When does Gonadal formation occur?
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once germ cell migration has occurred
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Oocyte multiplication an primordial follicle formation is complete by ? week in the female fetus.
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20 weeks
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What causes PROSTATE DEVLOPMENT to occur?
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DHT
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Wollfian duct responsive to T in fetal life action enhanced by ?
it is a product of the fetal TESTIS |
Fetal Androgen Binding Protein
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Response to androgens mediated through ? in most androgen-sensitive tissues.
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DHT
5-alpha-dihydrostosterone |
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Patients who exhibit disorders of Mullerian duct formation and fusion will have what type of external genitalia?
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Female External Genitalia
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Patients who have abnormalities of gonad formation and development will have what type of external genitalia?
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Female External Genitalia
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What are the clinical presentation of abnormalities of gonad formation and development?
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ambiguous genitalia
delayed puberty |
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What are the clinical presentations of disorders of fetal endocrinology?
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ambiguous genitalia
precocious pseudopuberty in male (early puberty onset) Abnormal puberty |
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What are the clinical presentations of disorders of Mullerian duct formation and fusion?
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Primary amenorrhea
pelvic masses, pain Pregnancy complications |
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In a person with menopause--
? and ? levels are low because it is manufactured by follicles this causes FSH levels to be ELEVATED |
estrogen
-->deficient estrogen will cause AMENORRHEA and HOT FLASHES INHIBIN --> made by follicles |
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True or False
Primordial Follicles become primary follicles INDEPENDENT of GONADOTROPINS. |
True
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Primary follicles become ATRETIC due to levels of what hormone?
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LH
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Primary follicles become ANTRAL follicles due to what hormone?
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FSH
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Antral follicles become graafian follicles due to what hormone?
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FSH
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oocyte multiplication and primordial follicle formation is complete by ? weeks in the female fetus
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20 weeks
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True or False
At age 38 women may be able to have kids but extremely unlikely as they are almost in menopause. |
True
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Even though no TDF is required for normal ovary formation--
a full set of essential ? are required for full formation of the ovary with retention of PRIMORDIAL FOLLICLES. |
a full set of essential genes from BOTH X chromosomes are required for full formation of the ovary with retention of primordial follicles
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A patient who exhibits a genotype (XX , XO) mosaicism
Do they have a Uterus, Fallopian Tubes, Cervix, and Vagina? |
Yes
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Complete Androgen Insensitivity syndrome--
will the patient have testis? |
Yes
but the patient will have exhibit female external characteristics |
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What makes about half of estrogen synthesis in a FEMALE?
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Adrenal Gland
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Granulosa cells stimulated by ? will take androgens and synthesize ESTROGEN.
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Granulosa Cells
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What can be used as a diagnostic feature to detect 21-Hydroxylase Deficiency?
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elevated levels 17-hydroxyprogesterone
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What causes increases synthesis of androgens in a person with 21-Hydroxylase deficiency?
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ACTH
low levels of CORTISOL due to the deficiency causes ACTH to be continuously secreted |
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How would it be possible for PARTIAL MASCULINIZATION of a female fetus?
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Congenital Virilizing adrenal hyperplasia
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