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27 Cards in this Set

  • Front
  • Back
At what week do migration of germ cells migrate into gonadal ridges?
5 weeks
True or False

A full set of essential genes from both X chromosomes are required for full formation of the ovary with retention of primordial follicles.
True
When does Gonadal formation occur?
once germ cell migration has occurred
Oocyte multiplication an primordial follicle formation is complete by ? week in the female fetus.
20 weeks
What causes PROSTATE DEVLOPMENT to occur?
DHT
Wollfian duct responsive to T in fetal life action enhanced by ?

it is a product of the fetal TESTIS
Fetal Androgen Binding Protein
Response to androgens mediated through ? in most androgen-sensitive tissues.
DHT

5-alpha-dihydrostosterone
Patients who exhibit disorders of Mullerian duct formation and fusion will have what type of external genitalia?
Female External Genitalia
Patients who have abnormalities of gonad formation and development will have what type of external genitalia?
Female External Genitalia
What are the clinical presentation of abnormalities of gonad formation and development?
ambiguous genitalia

delayed puberty
What are the clinical presentations of disorders of fetal endocrinology?
ambiguous genitalia

precocious pseudopuberty in male (early puberty onset)

Abnormal puberty
What are the clinical presentations of disorders of Mullerian duct formation and fusion?
Primary amenorrhea

pelvic masses, pain

Pregnancy complications
In a person with menopause--

? and ? levels are low because it is manufactured by follicles

this causes FSH levels to be ELEVATED
estrogen

-->deficient estrogen will cause AMENORRHEA and HOT FLASHES

INHIBIN
--> made by follicles
True or False

Primordial Follicles become primary follicles INDEPENDENT of GONADOTROPINS.
True
Primary follicles become ATRETIC due to levels of what hormone?
LH
Primary follicles become ANTRAL follicles due to what hormone?
FSH
Antral follicles become graafian follicles due to what hormone?
FSH
oocyte multiplication and primordial follicle formation is complete by ? weeks in the female fetus
20 weeks
True or False

At age 38 women may be able to have kids but extremely unlikely as they are almost in menopause.
True
Even though no TDF is required for normal ovary formation--

a full set of essential ? are required for full formation of the ovary with retention of PRIMORDIAL FOLLICLES.
a full set of essential genes from BOTH X chromosomes are required for full formation of the ovary with retention of primordial follicles
A patient who exhibits a genotype (XX , XO) mosaicism

Do they have a Uterus, Fallopian Tubes, Cervix, and Vagina?
Yes
Complete Androgen Insensitivity syndrome--

will the patient have testis?
Yes

but the patient will have exhibit female external characteristics
What makes about half of estrogen synthesis in a FEMALE?
Adrenal Gland
Granulosa cells stimulated by ? will take androgens and synthesize ESTROGEN.
Granulosa Cells
What can be used as a diagnostic feature to detect 21-Hydroxylase Deficiency?
elevated levels 17-hydroxyprogesterone
What causes increases synthesis of androgens in a person with 21-Hydroxylase deficiency?
ACTH

low levels of CORTISOL due to the deficiency causes ACTH to be continuously secreted
How would it be possible for PARTIAL MASCULINIZATION of a female fetus?
Congenital Virilizing adrenal hyperplasia