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10 Cards in this Set
- Front
- Back
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what is presynaptic facilitation? |
- in a consecutive pulse train, as the pulse increases, the response increases because residual concentration of calcium increases inside the presynaptic cell - result: increases probability of an AP and transmission is more efficient |
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how many pulses will cause depression instead of facilitation? |
- 10 to 15 pulses results in depression instead of facilitation |
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what type of cells are pyramidal cells? |
inhibitory cells |
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how many types of interneurons are there in CA1? |
26 types of interneurons in CA1 |
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what is the latency difference between an IPSP and EPSP? |
- IPSP has ~2x greater latency than EPSP - IPSP = 2 synaptic inputs - EPSP = 1 synaptic input |
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what does feed forward inhibition do? |
- decreases the temporal window - prevents overactive APs by increasing GABA, which decreases the temporal window for APs - allows precision by ensuring cells can reset between oscillations |
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what do GABA antagonists do to feed forward inhibition? |
- result in longer temporal window, resulting in hyperactive APs (e.g. seizures) |
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what is phase inhibition? |
- inhibition at the soma - very strong compared to inhibition at the dendrite - changes the RC components of the cell |
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what is tonic inhibition? |
- interneurons that constantly emit GABA to stop any APs |
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are release mechanisms of axons the same when releasing in layer 6 compared to layer 1? |
- No - release mechanisms are very specific and can be very different when just 1-2 um apart - there is target cell independence - the same stimulation can cause inhibition on EPSP (neuron) and facilitation on IPSP (interneuron) - each bouton handles Ca input independently |
