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14 Cards in this Set
- Front
- Back
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H1 antag 1st gen
Hydroxyzine |
Long acting drug
Widely used for allergies Also used as mild anxiolytic (reduce anxiety) |
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H1 antag 1st gen
Cyclizine Meclizine |
Indicated for motion sickness
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H1 antag 1st gen
Promethazine |
Indicated for:
1) allergic rxn 2) Prophylaxis 3) motion sickness 4) post-op pain (adjunct to analgesics) |
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H1 antag 1st gen
Azelastine |
The only one that can be adminstered with nasal spray
Inhibits release of histamine via nasal spray Increases motility of bronchial cilia May also be adminstered as ophthamlic agent Metabolized to desmethylazelastine |
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H1 antag 1st gen
Diphenhydramine |
To help sleep (sedating effect)
may be used in parkinson's |
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H1 antag 2nd gen defined by
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Almost free of sedation and autonomic effects
Developed for use in chronic conditions Extremely long acting and far less lipid soluble than the first generation |
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H1 antag 2nd Gen
Fexofenadine Loratadine Cetrizine |
indicated for
Allergic reactions Urticaria dermatitis Hay fever Motion sickness Sedation Nausea Vomitting |
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What will happen if you have too high of a dose of H1 antagonists?
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activation of cholinergics
dry mouth and neuro effects |
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What are the four H2 antagonists available on the market today?
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Cimetidine
Ranitidine Famotidine Nizatidine |
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What are the two most potent H2 antagonists?
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Famotidine
Nizatidine |
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If you are trying to preven a gastric ulcer, what type of drug will u want to use?
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Any of the below:
Cimetidine Ranitidine Famotidine Nizatidine |
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What are the details of H2 antagonists
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HL of 1-3 hours
Relatively non-toxic |
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Although H2 blockers can be used to treat Zollinger-Ellison syndrome, whats the better treatment?
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Proton Pump inhibitor
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What does cimetidine inhibit and whats the significance?
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Inhibits CYP-450 isoenzyme
Significant drug interaction Also... Antiandrogen effects (will cause gynecomastic in males) |
