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27 Cards in this Set

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EBM Definition
Conscientious, explicit, judicious use of current best evidence in making decisions about the care of individual patients.
Practice of _____ means integrating individual clinical expertise with the BEST available external clinical evidence from systematic research.
EBM
Type of source where information is FIRST presented
Primary Source

ex: research journals, theses, conference proceedings, government docs.
Type of source where information is summarized/edited
Secondary Source

ex: textbooks, magazines, newspapers, encyclopedias
inference of a generalized conclusion from particular instances
Inductive reasoning
inference in which conclusions about particulars follows necessarily from general or universal premises
Deductive reasoning
The strength of our inference is dependant on:
differences observed NOT being due to chance
AND
our sample being representative of the whole population
Steps in conducting/reporting research
1) Question
2) Background knowledge (literature review)
3) theory/hypothesis and model
4) Design for testing hypothesis (methods)
5) measurable outcome (data)
6) analyze outcomes (stats)
7) Conclusions
Definition of operationalization
Converts abstract notions (concepts) into concrete measurable terms (variables)

ex: Intelligence (concept) measurable by IQ tests (variable)
A characteristic or quality that takes on different values and that changes from one person to the next
Variables
Variables: Measurements must be ___ and ____
precise (sufficiently exact); reliable (repeatable)
Independent Variable (IV)
the presumed cause

ex: Smoking
Dependent Variable (DV)
the presumed effect

ex: Lung cancer
Anticedent variable
occur before the independent variable
Intervening variable
occur after the independent variables
Confounding variables
might cause differences in the dependent varibales AND are distributed differently in the study and control group
Confounding variables can be due to ___ or _____ and need to be controlled for/eliminated.
Chance (random error); Bias (systematic error)
Simple hypothesis have ___ (#) IV and ___ DV
1; 1
Complex hypothesis have _____(#) IV and/or ____ DV
2 or more; 2 or more
Major methodologic challenge:
Designing studies that are NOT BIASED!!
a condition that consistently produces results which depart from true values; results that are NOT seen in the general population
BIAS
Reliability = _______
reproducibility
in general, results based on ____ (larger/smaller) samples and ____ (single/multiple) measurements are MORE reliable.
Larger samples; Multiple measurements
Internal Validity
Researchers are actually studying what they propose to be studying.
External vailidity
results that can be generalized to subjects who are NOT in the study
Study population should....
represent the Target Population
In _____ samples, each member of the population has an equal probability of being included.
Random Samples