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16 Cards in this Set
- Front
- Back
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Cell wall synthesis inhibitors |
Vancomycin B-lactams bacitracin |
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B-lactams - what is special about these |
bind to penecillin-binding proteins--> inhibit transpeptidase rxn that crosslink
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B-lactams - what are they |
penecillin cephalosporin carbapenems monobactams |
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Penecillin spectrum -extended also |
G+ and spirochetes Antistaphylococcal -G- +/- b-lactamase inhibitor |
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B-lactamase inhibitors - how are these used |
Clavulanic acid Sulbactam Tazobactam added to penecillin to avoid inactivation |
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clavulanic acids |
Amoxicillin (ear infections), ticarcillin |
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sulbactam |
ampicillin |
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Tazobactam |
piperacillin |
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Penicillin Adverse effects |
drug-induced hypersensitivity--> anaphylactic shock serum sickness interstitial nephritis rash |
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Non-allergic Amoxicillin Rash |
starts on trunk -may indicate mono maculopapular or morbilliform |
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Cephalosporins 1st 4th limitations |
1-4 generations 1= G+ 4= G- -limited anaerobic -more resistant to B-lactamases |
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Cephalosporins -adverse effects |
5% cross-sensitivity -platelet dysfunction and bleeding w/ cefotetan |
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Carbapenems -uses -AE |
Broad spectrum *reserved for serious infections -seizures& renal insufficiency -cross-sensitivity w/ pcns |
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Monobactam -use -AE |
aztreonam -G- aerobes only -Hypersensitivity |
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Vancomycin -uses -AE -how it is given |
Glycopeptide Ab -G+ MRSA -Red man syndrome- hypotension and face rash -oto and nephrotoxicity -IV |
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Lipoglycopeptides -what are they -uses -AE |
Dalbavancin, Oritavancin, Telavancin -MRSA -Red man syndrome |
