Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
26 Cards in this Set
- Front
- Back
|
Statins--Targets
|
↓ LDL**
↓ P (stroke) (↓ TG & ↑ HDL) |
|
|
Statins--MOA
|
HMG CoA reductase Inhibition
|
|
|
Statins--C/I
|
Liver dx (thus, screen for liver E)
|
|
|
Statins--AE
|
Myopathy
|
|
|
Statins--DDI
|
● Fibric acids
● HMG-CoA Reductase Inhibitors ● Alcohol ● Barbiturates OK w/ BA sequestrants, Nicotinic Acid, or Selective CHL Absorption Inhibitors (e.g. Zetia) |
|
|
BA Sequestrants--examples
|
● Cholestyramine
● Cholestipol ● Colesevalam |
|
|
BA Sequestrants--Targets
|
↓ LDL (moderately)**
(↓ TG (barely) & ↑ HDL (barely)) |
|
|
BA Sequestrants--C/I
|
HYPER-TG-emia (>400)
|
|
|
BA Sequestrants--AE
|
● GI problems
● ↓ Drug Absorption |
|
|
BA Sequestrants--DDI
|
● Niacin
● Ezetimibe ● Fluvastatin ● Fibric Acid OK w/ Statins |
|
|
Nicotinic Acid--Targets
|
↓ TG **
↑ HDL ** (↓ LDL) |
|
|
Nicotinic Acid--MOA
|
Alters lipoprotein synthesis
|
|
|
Nicotinic Acid--C/I
|
● Severe gout
● Severe liver dx |
|
|
Nicotinic Acid--AE
|
● Flushing
● HYPERglycemia ● Gout ● Hepatotoxicity |
|
|
Nicotinic Acid--DDI
|
● BA sequestrants
● Ethanol ● Warfarin ● Vasodilators OK w/ statins, fibric acid & selective CHL absorption inhibitors (e.g. Zetia) |
|
|
Selective CHL Absorption Inhibitors--Targets
|
↓ LDL
|
|
|
Selective CHL Absorption Inhibitors--MOA
|
↓ CHL absorption across intestinal border
|
|
|
Selective CHL Absorption Inhibitors--C/I
|
● elderly
● hepatic dx |
|
|
Selective CHL Absorption Inhibitors--AE
|
●yellowing of the skin or eyes
●dark yellow or brown urine ●muscle pain, tenderness, cramps, or weakness ●unusual tiredness or weakness |
|
|
Selective CHL Absorption Inhibitors--DDI
|
● Fibric Acids
● BA Sequestrants ● Warfarin OK w/ Nicotinic Acid & Statins |
|
|
Fibric Acid--Targets
|
↓ TG **
↑ HDL ** [↓LDL(5-20%)in PT's w/o hyperglycemia] |
|
|
Fibric Acid--MOA
|
PPAR agonist ↑ LPL activity
|
|
|
Fibric Acid--C/I
|
● Severe hepatic
● Renal insufficiency |
|
|
Fibric Acid--AE
|
●dyspepsia
●GI distress ●Gallstones ●Myopathy |
|
|
Fibric Acid--DDI
|
● Ezetimibe
● BA Sequestrants ● HMG Co-A Reductase inhibitors OK w/ Nicotinic Acid |
|
|
Fibric Acid--DDI
|
● Ezetimibe
● BA Sequestrants ● HMG Co-A Reductase inhibitors OK w/ Nicotinic Acid |
