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18 Cards in this Set
- Front
- Back
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What is the name of the newest statin that is minimally metabolized by the liver?
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Pitavastatin
Aka: Livalo |
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What lipid-lowering drugs have not effect on TG levels (may increase them)?
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Bile Acid Resins
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What is First Line Therapy for lowering LDL?
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Statins
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When should you stop statin therapy?
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if AST and ALT levels are > 3 times ULN (upper limit of normal)
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You should never use statin therapy with these types of drugs?
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CYT P 450 inhibitors
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T/F Statins are contraindicated in pregnancy and in nursing mothers.
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True! Statins are Cat. D.
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Why should you be cautious in using combination therapy of Statins and Fibrates?
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puts patients at a higher risk for Myopathy and Rhabdomyolysis!
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When is the risk for myopathy enhanced?
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-High dose of statins
-Renal insufficiency -Concomitant meds: *Itraconazole *Ketoconazole *Cyclosporin A *Erythromycin -Age > 70 |
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What are the main AE of Bile Acid Sequestrants?
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GI:
*Constipation *Bloating *Fullness *Abdominal pain *Nausea *Flatulence |
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T/F Pts should take Bile Acid Sequestrants 1 hour before or 4 hours after other meds
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True!! They decrease absorption.
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These drugs are used as combo therapy in women considering pregnancy to lower their LDL levels
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Colesevalam (Cat. B)
Colestipol (Cat. C) |
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What are contraindications of Nicotinic acid Derivatives?
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1. Chronic liver disease
2. Severe gout 3. Relative: *DM *Hyperuricemia |
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What are the monitoring parameters for Nicotinic Acids?
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1. Baseline LFTs, uric acid, and fasting blood sugar
2. Then 6-8 weeks after therapy and then as needed, annually. |
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What is the most effective clinical use of Nicotinic Acids?
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to RAISE HDL-C levels!
(also useful in lowering TG levels: good for combo therapy on pts. who dont have high LDL level)s |
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What are the most common AE of Fibrates?
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GI
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Ezetimibe is used alone with ______ and in combo with ______
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Diet, Statins!
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What is the primary use of Fibric Acid derivatives (Fibrates)?
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to LOWER TG!!
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What is Omacor aka Omega-3 Acid Ethyl Esters aka Lovaza useful for?
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decreasing TG levels in addition to diet modifications
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