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24 Cards in this Set
- Front
- Back
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Hypothalamic/ Anterior Pitu
Growth Hormone-Releasing Hormone (GHRH) mech? |
-released hypothalamus
-preserves feedback on pituitary -inhibited by somatostatin |
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Hypothalamic/ Anterior Pitu
Somatostatin -GHIH -SRIH |
-inhibit release GH, insulin, glucagon, gastrin
-Octreotide (for diarrheas, and olther) |
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Hypothalamic/ Anterior Pitu
GH |
-anterior pituitary
-target liver and bone -acts like glucose first then opposite (which is stronger) -use fat as energy source |
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Hypothalamic/ Anterior Pitu
Gonadotropin-Releasing Hormone GnRH |
Pulsatile- up LH and FSH
Continous- block release -analog--> Leuprolide -for sex steriod tumors, early puberty ... |
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Hypothalamic/ Anterior Pitu
Follicle stim. hormone |
stimulate gametogenesis & spermatogenesis
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Hypothalamic/ Anterior Pitu
thyroid stim. hormone |
from anterior pituitary
-for thyriod carcinoma -stim radioactive I131 uptake |
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Hypothalamic/ Anterior Pitu
corticotropic releasing hormone |
-from hypothalamus
-negative feedback -stim ACTH release |
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Hypothalamic/ Anterior Pitu
Adrenalcorticotropin ACTH |
-anterior pituitary
-analog--> Cosyntropin -increase serum levels cortisol -treat infantile seizures |
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Hypothalamic/ Anterior Pitu
Human Chorionic gonadotropin |
-similar to LH
-basis of preg test |
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Hypothalamic/ Anterior Pitu
human menopausal gonadotropin |
-urine postmenopausal women
-mostly FSH (some LH) |
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Hypothalamic/ Anterior Pitu
Prolactin |
anterior pituitary
-kinda looks GH -milk production -Prolactin inhibiting factor--> dopamine from hypothal Bromocriptine- selective D2 agonist (down PL release) |
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oxytocin
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-stim milk ejection
-induce labor' -love drug? |
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vasopressin (ADH)
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hypothalamus
-vasoconstriction -anti-diuresis -inhibited by cold/ethanol -deficiency--> diabetes insipidus(high urine output) Desmopressin acetate- agonist, 4000x V2 activit over V1 |
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Hypothyriodism
desiccated thyroid |
foreign version cause hypersensitivity
-dont know T3/T4 content |
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Hypothyriodism
Liothyronine |
-synthetic T3
-shorter T1/2 than T4 -more side effects -best used with T4 |
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Hypothyriodism
Fixed Ratio (liotrix) preparations |
4:1
T4:T3 mix T3-->headaches, palp, tremor |
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Hypothyriodism
Levothyroxine |
DOC for thyroid hormone replace
-T4, predicatble 1 week T1/2 -treat myxedema coma -IV |
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Hyperthyroidism
-Propranolol |
-reduce peripheral symptoms
-Bblocker which inhibits T4 to T3 |
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vHyperthyroidism
Thionamides -Propylthiouracil(PTU) -Methimazole |
mech-inhibit iodine ox./ inhibt thyriod peroxidase
doesnt work until previous converted T3 runs out warning- agranulocytosis- bone marrow -dermatological reactions -use PTU for thyriod storms |
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Hyperthyriodism
Radioactive Iodine |
-radioactive I131 destroys cells in thyriod
-high cure rate -no surgery -3-6 month for response -not in preg |
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Hyperthyroidism
Anion inhibitors -perchlorate -thiocyanate |
compete w/ I uptake to thyriod
perchlorate 10x potentcy thio |
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Hyperthyroidism
Iodides |
-use in thyriod storm
-Lugols soln and saturated solution potassium iodide -inhibit uptake of iodide by downregulating symporter -should not be used monotherapy |
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Hyperthyroidism
Iodinated contrast media |
rapidly inhibits conversion of T4 to T3 in liver, kidney, pituitary gland
-treatment for thryiod storm |
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Hyperthyroidism
subtotal thyroidectomy |
-partial removal of gland
-difficult procedure |
