Dt, Adrenergic Pharm

Front 1

this receptor is located -->
-radial muscle in the eyes
- arterioles in the skin
- veins
- bladder trigone and sphincter
- male sex organs
- liver
-kidney

Back 1

Alpha one receptors

Front 2

alpha 1 stimulation of radial muscle causes?

Back 2

- radial muscle contraction = mydriasis

Front 3

alpha 1 stimulation of arterioles in skin and viscera?

Back 3

- contraction --> incrse tpr , diastolic pressure, afterload

Front 4

alpha 1 stim of veins causes what?

Back 4

venous contraction, incrsd vns return, increase preload

Front 5

alpha 1 + of bladder / trigone ?

Back 5

contraction --> urinary retention

Front 6

alpha 1 stimulation of vas deferens?

Back 6

ejaculation

Front 7

alpha 1 stim of liver ?

Back 7

INCREASE in GLCYOGENOLYSIS --> causes increased blood glucose levels

Front 8

alpha 1 stim of kidney?

Back 8

DECREASE renin release

Front 9

Alpha 2 receptors are located on the presynpatic terminals and do what ?

Back 9

inhibit the release of NE and its synthesis

Front 10

alpha 2 stimulation on platelets causes them to do what ?

Back 10

platelets aggregate together

Front 11

stimulation of this receptor can a DECREASE IN INSULIN secretion

Back 11

alpha 2 stimulation causes a DECREASE in INSULIN release

Front 12

B1 receptors are located where?

Back 12

- SA,AV node, Atrial and ventricular muscle, purkinje-his bundle , and the kidney

Front 13

B1 stimulation of SA/Av node causes

Back 13

increase in HR (sa), Conduction velocity (av)

Front 14

B1 stimulation of atria and ventricular muscle

Back 14

increased force of contraction, conduction velocity and O2 DEMAND

Front 15

B1 stimulaton of his-purkinje?

Back 15

increased automaticity and conduction velocity

Front 16

B1 stimulation of kidney causes?

Back 16

increased Renin release

Front 17

B2 receptors are located where in the body? what r their fx?

Back 17

- all blood vessels
- uterus (relaxation)
- bronchioles (dilation)
- skeletal muscle (incrsd glycognolysis --> contractility ~ tremor)
-Liver (incrsd glycogenolysis --> incrsd blood glucose)
- Pancreas (incrsd insulin secretion)

Front 18

Dopamine (D1) receptors are located where ? (peripheral)

Back 18

- renal, mesenteric and coronary vasculature
- VASODILATION --> incrse RBF, GFR, NA+ secretion

Front 19

alpha 1 receptors , g protein?

Back 19

Gq coupled --> increse PLC = Incrsd IP3, DAG , CA2+

Front 20

ALPHA 2 receptors ?

Back 20

Gi coupled --> inhibitory action
- dcrse cAMP

Front 21

B1,2, D1

Back 21

G-STIMULATORY coupled
= increase Adenylyl cyclase --> increase cAMP

Front 22

name 2 drugs that are ALPHA - 1 AGONISTS

Back 22

Phenylephrine
Methoxamine

Front 23

moa of alpha 1 agonists?

Back 23

increase TPR, BP

Front 24

uses of phenylephrine?

Back 24

nasal decongestant and opthalmic uses (mydriasis without affecting ability to accomodate)

Front 25

uses of METHOXAMINE?

Back 25

paroxysmal atrial tachy --> through the effects of increased vagal reflex

Front 26

name 2 main Alpha 2 agonists?

Back 26

- clonidine
- methyldopa

Front 27

moa of Alpha 2 agonists?

Back 27

stimulate the prejunctional receptors in CNS to DECREASE CNS SYMPATHETIC OUTFLOW

Front 28

what is the primary use of alpha 2 agonists?

Back 28

mild/moderate hypertension

Front 29

Beta 1 agonist fx?

Back 29

Increase HR, SV, CO and INCREASED PULSE PRESSURE

Front 30

beta 2 agonist fx?

Back 30

decrease TPR , BP

Front 31

this drug has B1=B2, used for bronchospasm, heart block, and brady arrythmias

Back 31

Isoproterenol

Front 32

side fx of Isoproterenol?

Back 32

flushing
angina
arrythmias

Front 33

this drug stimulates B1 MORE than B2 and is often used in the treatment of heart failure

Back 33

Dobutamine

Front 34

These 2 drugs are BETA non-selective agonists?

Back 34

Isoproterenol
Dobutamine

Front 35

this drug is B2 selective agonist, and is use in premature labor

Back 35

RITODRINE

Front 36

B2 selective agonist used in the Rx of asthma

Back 36

Salmeterol
albuterol
terbutaline

Front 37

These 2 drugs are MIXED-ACTING AGONISTS OF ALPHA AND BETA RECEPTORS

Back 37

Norepinephrine, Epinephrine

Front 38

Norepinephrine mainly hits which receptors?

Back 38

alpha 1,2 and beta 1

Front 39

alpha 1 , B1 affects of norepi?

Back 39

alpha 1 = increase tpr, bp
b1 = increase HR, SV, CO, Pulse pressure

Front 40

does epinephrine hit all 4 receptors?

Back 40

yes, epinephrine hits alpha1,2 and B1,2

Front 41

low dose epi fx?

Back 41

B1= incrse HR, SV, CO, pulse pressure
B2= dcrse TPR, BP

Front 42

Medium dose epi fx?

Back 42

B1, B2 and ALPHA 1 (Increase TPR,BP)

Front 43

high dose epi fx? similar to NE

Back 43

b1,b2,alpha1 and INCREASED POTENTIAL FOR REFLEX BRADY

Front 44

B2 specific fx?

Back 44

-smooth muscle relaxation of bronchioles, uterus and blood vessels

Front 45

metabolic b2 fx?

Back 45

- incrse glycogenolysis in muscle and liver
- increase gluconeogenesis
- incrse mobilization and use of fat

Front 46

how do u reverse an overdose of epinephrine?

Back 46

- use alpha1 blocker to reverse hypertension to hypotension

Front 47

how did epi cause the hypertension in the overdose?

Back 47

epi caused the PREDOMINANT alpha 1 tone on the vasculature

Front 48

uses of NE and E?

Back 48

- cardiac arrest
- help local anesthetic
- hypotension
- anaphylaxis and asthma (EPI ONLY)

Front 49

this drug causes the RELEASE of NE from the mobile pool in the presynaptic neuron?

Back 49

Tyramine
- red wine, cheese

Front 50

what can tyramine and MAOa inhibitors cause?

Back 50

hypertensive crisis!

Front 51

moa of amphetamines?

Back 51

causes central release of DA,NE,5HT

Front 52

use of amphetamines?

Back 52

methylphenidate --> narcolepsy and adhd

Front 53

ephedrine?

Back 53

cold medications

Front 54

these 2 drugs are REUPTAKE INHIBITORS

Back 54

COCAINE
TCA'S

Front 55

name 2 NON-SELECTIVE ALPHA RECEPTOR BLOCKER

Back 55

- phentolamine (competitive inhibitor; iv only)
- phenoxybenzamine (irreversible blocker)

Front 56

fx of blockage of alpha 1 receptor?

Back 56

dcrse tpr, bp
- used in htn
- pheochromocytoma
- bph (alpha 1 selective blocker)

Front 57

where is MAOa located?

Back 57

mainly in LIVER
- but metabolizes NE,5HT AND TYRAMINE anywhere in the body

Front 58

Mao B located?

Back 58

brain - metabolizes DOPAMINE

Front 59

-zosins? what type of drug?

Back 59

SELECTIVE ALPHA1 BLOCKER

Front 60

fx of -zosins?

Back 60

relaxes bladder sphincters and helps complete the voiding

Front 61

Yohimbine, Mirtazapine

Back 61

selective alpha 2 blocker

Front 62

what is the only way to prevent prostate growth?

Back 62

block DHT w/ 5 ALPHA REDUCTASE inhibitors (finasteride)
- also used for male pattern baldness

Front 63

BEAM beta blockers moa?

Back 63

B- betaxolol/
E- esmolol
A- atenolol/ acebutolol
M- metoprolol

Front 64

Pindolol, Propranolol, Timolol moa?

Back 64

Beta non-selective blockers

Front 65

B1 blockade causes?

Back 65

- dcrse hr,sv,co, renin release, aqueous humor release

Front 66

B2 blockade causes?

Back 66

can cause bronchospasm in asthmatics and vasospasm

Front 67

make sure you AVOID bb's in which types of patients?

Back 67

- asthmatics
- people with reynaud's and prinzemetals angina

Front 68

bb w/ most sedative fx?

Back 68

propranolol

Front 69

2 bb's w/ ISA activity

Back 69

acebutelol, pindolol
- also have no change in blood lipids

Front 70

propranol also does what to thyroid hormones?

Back 70

inhibits 5' deiodinase (t4 conversion to t3)

Front 71

this bb is used for essential tremors?

Back 71

propranolol ; also used for performance anxiety, migraine and thyrotoxicosis

Front 72

ALL bb's should be avoided in which patients?

Back 72

DIABETICS
- can mask hypoglycemia

Front 73

this bb has no cns entry

Back 73

atenolol

Front 74

bb used in glaucoma?

Back 74

timolol

Front 75

this bb has a combined alpha-1 and BB activity?

Back 75

labetolol and carvedilol
- used in chf

Front 76

ISA (instrinsic sympathomimetics) activities means what ?

Back 76

- bb's act as partial agonists
- less bradycardia
- slight vaso/bronchodilation
- minimal change in the blood lipids

Front 77

main uses of bb's?

Back 77

angina, htn, and post-mi
- antiarrythmics --> class 2 drugs (propranolol, acebutolol, esmolol)