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90 Cards in this Set
- Front
- Back
Psychosis
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-prominent hallucinations or delusions
-Sx don't occur only during episode of delirium -Evidence to support med or substance related cause from lab, hx or physical -disturbance not better accounted for by psychotic d/o not substance induced |
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Schizophrenia
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2 or more for 1 month
-delusions -hallucinations -disorganized speech -grossly disorganized or catatonic behavior -Negative Sxs (like flattened affect) R/o med, neuro, substance induced At least 6 mo (includes prodromal or residual periods where above criteria not met) |
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schizoaffective d/o
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-meet affective d/o criteria
-delusions or hallucinations for 2 weeks in absence of mood sxs. -have mood sxs for substantial portion of psychotic illness |
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MDD
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5 of symptoms including 1 or 2 for 2 weeks
-15% chance of committing suicide later in life |
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Manic
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elevated mood for 1 week and 3 of following. (4 need to be present if mood is irritable)
-75% have psychotic features |
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Mixed episode
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both criteria are present for nearly everyday and are filled for 1 week
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hypomanic
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Difference from mania
-4 day duration -no psychotic features -no social impairment |
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SAD triad
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-irritability
-carbohydrate drawing -hypersomnia |
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Epidemiology of MDD
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-15% lifetime prevalence
-age is 40 -2x in women -25-50% in elderly -loss of parent b/4 age 11: later development of major depression -1st degree relatives=2-3x more likely to have MDD |
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Course and Prognosis of MDE
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-clears up after 6mo-1 year
-episodes occur more frequently as disorder progresses -risk of subsequent MDE is 50% w/in 1st 2 years after 1st episode -15% commit suicide |
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5HT syndrome
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-autonomic instability
-hyperthermia -seizures -coma and death |
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adjunctive therapy for SSRI nonresponders
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-T3/T4
-Li -L-Tryptophan |
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ECT
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-premedicate with Atropine
-general anesthesia -muscle relaxant -retrograde amnesia |
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Types of depression x4
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1)melancholic: anhedonia; early morning awakening; anorexia; guilt
2)atypical: MAOI; hyperphagia; hypersomnia; leaden paralysis; hypersensitivity to personal rejection 3)Catatonic: catalepsy; purposeless motor activity; negativism/mutism; echolalia; bizarre postures 4)psychotic |
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Bipolar I epidemiology
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-75% concordance in twins
-8-18x more likely in 1st degree relatives -women and men affected equally -ECT works well, need more sessions than MDD |
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Dysthmic disorder
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-No discrete episodes, majority of time you are depressed for at least 2 years (In kids, for 1 year)
-not w/o symptoms for >2 months at a time -no major depressive episode DDs: 2 Ds: 2 years, 2 listed criteria, never asympto for >2 months -Concentration; hopelessness; appetite; insomnia/hypersomnia; low self esteem; low energy |
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Course and PX of dysthmic d/o
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-20% develop major depression
-20% get Bipolar ->25% have lifelong sxs -onset b/4 25 in 50% -never w/psychotic features |
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cyclothymic
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-2 years of hypomania and depression w/many periods (diff from rapid cycling BPD).
-never Sx free for >2 months -popular w/Borderlines |
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Panic attack
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-can also occur w/sp phobia and PTSD
-subside w/in 25 min, rarely last >1 hr -"sudden rush of fear" -Palpitations; Abdominal distress; Numbness/nausea; Intense fear of death; Choking/chills/CP; sweating/shaking/SOB (4 of them) |
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Panic disorder
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-w/or w/o agoraphobia
1)No precipitant for panic attacks 2)At least one of the attacks has been followed by a min of 1 month of: worry of the attacks, change in behavior to avoid the attacks -1st episode: may think they are going insane -anticipatory anxiety -usually 2x/week -last 20-30 min |
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Specific phobia/social phobia
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-intense anxiety when in situation that is tried to be avoided
-patient knows fear is excessive -if <18, present for >6mo -phobias are most common mental d/o -F>M -substance abuse is common -neuro: too much NE, so B blockers -use paxil for social ph; benzo or B blcok for sp ph during desensitize |
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OCD
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-egodystonic (have insight)
-obsessions: suppresses thoughts, person knows they are product of his mind -compulsion: no link b/w behavior and distress, but try to calm down w/behavior -obsessions of locking door, symmetry |
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PTSD
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-symptoms for 1 mo
-persistent sxs of arousal -numbing of responsiveness (ltd affect, detachment feelings) -comorbid w/substance abuse and depression |
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Acute stress disorder
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PTSD but sx at most for 1 mo
-event occured <1 mo ago (PTSD: event at any time in past) |
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GAD
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-persistent, excessive anxiety and hyperarousal for 6 mo
-difficult to control the worry -3 of following: restless, muscle tension, fatigue, poor concentration, sleep problems -more women -pts seek help b/c of medical problem: fatigue or muscle tension |
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Adjustment d/o
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-Sxs begin w/in 3 mo after event; end w/in 6 mo
-severe distress in excess -not bereavement -resolve w/in 6 mo after terminated stressor -supportive TX is best; pharm for sxs (depression, insomnia, etc) |
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Paranoid PD
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-suspicion of others
-preoccupation of trustworthiness -reluctant to confide in others -persistent grudges -quick to counterattak M>F -may have transient psychosis: give meds -psychotherapy |
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PMDD
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-not severe or sufficient duration for MDD
-remittance of sxs in a week |
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most predictive factors for suicide
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age >45 >> EtOH dependence>>rage or violence >>prior suicide attempt >> male gender
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worst withdrawal
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-etoh and benzos
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substance abuse
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-failure to fulfill obligations at home, work
-use in dangerous situations -recurrent legal problems -continued use despite interpersonal problems |
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receptors involved in etoh
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activates: i)GABA ii)5-HT
Inhibits: i)glutamate receptors |
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what do etoh, meoh, and ethylene glycol cause
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metabolic acidosis with increased anion gap
-1st step in management is CT to r/o subdural hematoma |
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treatment of etoh intox
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ABCs and lytes and acid-base status
F.S to exclude hypoglycemia thiamine, naloxone, folate No gastric lavage can give SSRI |
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EtOH w/drawal sxs:mild, moderate, severe
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mild: irritable, tremor, insomnia
moderate: diaphoresis, fever, disorientation severe:Seizure, DTs 5% get DTs, 15-20% mortality rate untreated |
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treatment of DTs
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benzos tapered off
nutritional stuff MgSO4 for postw/d seizures |
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wernicke:
korsakoff |
w: ataxia, nystagmus, confusion
K: antero/retrograde amnesia; confabulation |
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causes of death for cocaine
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seizure
arrhythmia respiratory depression drug screen pos x3 days |
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treatment of intox of coke
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mild-moderate agitation: benzo
severe: haldol symptomatic support |
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treatment of dependence on coke
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psychotherapy
TCAs DA agonists: amantadine, bromocriptine |
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diff b/w classic amphetamines and designer
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classic: cause release of DA from nerve endings, stimulant effect
designer (MDMA): release DA and 5HT, getting stim and hallucinogenic |
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MOA PCP and ketamine
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hallucinogen antagonizing NMDA glutamate receptors
activates DA neurons |
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Treat PCP intox
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[PCP can cause seizure and coma]
i)Monitor BP, Temp, Lytes ii)Acidify urine w/NH4Cl and Vit C iii)Benzos for agitation and anxiety, spasms and seizures iv)Haldol for psychotic symptoms/agitation |
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Eval for PCP
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elevated CPK; AST
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Benzos/sedative hypnotics:
i)Eval ii)Treat |
i)1 week positive urine screen
lytes, EKG ii) ABCs, charcoal flumazenil (causes seizures also) barbiturate: alkalinize urine w/NaHCO3 |
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Triad of opioid overdose
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Rebels admire morphine
i)resp depression ii)altered mental status iii)miosis (pinpoint) |
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opioid w/d
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-rhinorrhea
-piloerection -yawning -sweat/lacrimation |
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caffeine moa
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-adenosine antagonist, causing increased cAMP
-stimulant effect via DA system |
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Defn of cognitive d/o
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affect memory, attention, orientation, judgment
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necessary minimum workup of dementia
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CBC
TFTs VDRL CT B12 Folate Electrolytes |
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Treatment of delirium
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-treat underlying cause
-antipsychotics 1st line (seroquel). Haldol PO/IM but not IV b/c of torsades |
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causes of delirium
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-Iatro: BP meds, insulin, H2 receptor blocker, antiparkinsonians
-O2 hypoxia: bleed, central venous, pulm -seizures: post ictal |
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diff b/w delirium and dementia
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-delirium has immediate/recent memory impaired; dementia recent and longterm impaired
-symptoms worse at night in delirium; stable in dementia -EEG changes in delirium |
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aphasia
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problems with speech and understanding
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Neurophys of AD
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-decreased level of Ach (loss of NE neurons in locus ceruleus of brainstem)
-decreased NE: Basal nucleus of Meynert of midbrain. |
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Diff b/w vascular dementia and AD
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-vascular caused by small brain infarcts, so pts w/focal neuro problems (hyperreflexia or paresthesia)
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What are the cortical dementias and what are subcortical?
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Cortical: AD, FTD, CJD
Subcortical: NPH, Huntingtons, Parkinson's, multi-infarct Cortical=cognitive subcort=affective and movement d/o |
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Treat Parkinson's as last resort
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thallotomy or pallidotomy
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CJD hallmarks
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myoclonus
EPS ataxia long latency period b/w exposure and dz onset EEG=periodic sharp waves/spikes |
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delirum, fever, nuchal rigidity, photophobia
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meningitis; need LP
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delirium+dilated pupils+tachycardia
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utox; drug intox
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delirium+elevated BP+papilledema
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HTNive encephalopathy
CT/MRI |
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treat delirium
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FEUD
Fluid Electrolytes Underlying Cause Drug w/d. Avoid BeNZOS! |
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Methods of gathering information in children
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-play, stories, drawing
-K-ABC: Intelligence for 2.5-12 -WISC-R: IQ for 6-16 -PIAT: academic achievement |
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MR DX criteria
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-IQ <70
-Onset b/4 age 18. Most are mild (50-70 IQ) |
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Types of learning d/o and what must be r/o?
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-R/o hearing or visual deficit
-Reading d/o: more boys -Math d/o: girls -Written expression: unknown. |
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Most common outpt diagnosis in kids?
-risk of developing ASPD? -pharm therapy? |
CD
-40% -antipsychotics or Li for aggression -SSRI for impulsivity, irritability, mood lability |
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Diff of ODD from CD?
-comorbidity? |
-ODD doesn't involve violation of basic rights of others. Bad towards adults but good w/peers
-ADHD, substance abuse, mood d/o |
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what are the symptom categories for autism (x3)
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-problems w/social interaction
-communication problems -repetitive and stereotyped behavior and activities |
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treatment of autism
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-Neuroleptics: control aggression, mood lability
-SSRi: repetitive actions |
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etiology of Tourettes
-treat tourettes |
-impaired regulation of DA in Caudate
-clonidine or pimozide (DA-R antag) |
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Enuresis r/o dx's
-treatment of enuresis -DX: |
-urethritis, diabetes, seizures
-ADH or TCAs (imipramine) -2x/week x3 months |
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etiology of enuresis
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-genetics
-psychological -small bladder or low nocturnal levels of ADH |
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r/o dx's for encopresis
Comorbidity |
-metabolic: hypothyroid
-GI: anal fissure, IBD -dietary factors Comorbid w/CD and ADHD |
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dissociative amnesia
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-1 episode of inability to recall imp personal info, usually involving traumatic or stressful event
-often unable to recall name or imp info but remember obscure information |
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dissociative fugue
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-unaware that they have forgotten anything (unaware of their amnesia)
-assume new id and occupation after arriving to new place -usually a response to traumatic event -lasts up to days, forget their fugue |
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dissociative identity disorder
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-2 or more id's that recurrently take control of their life
-can't recall other personality's info -sxs like Borderline; same comorbidity as fugue and amnesia; 1/3 suicidal |
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levels of __ and impulsivity and aggression? (impulse d/o's)
-predisposing factors |
-5HT
-child abuse, head trauma, seizures |
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anorexia dsm
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-<15% ideal body weight
-fear of being fat -amenorrhea -distorted body image |
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Primary insomnia
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-problem falling or maintaining sleep
-at least 3x/week x 1month |
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narcolepsy
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-cataplexy (lose tone ass'd w/laughter)
-short REM latency -sleep paralysis -hypnagogic or hypnopompic -repeated, sudden attacks of sleep in daytime x3months |
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hepatic encephalopathy
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-asterixis
-tremors -increased DTR -personality change -change in cognitive ability |
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HIV dementia
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-MMSE goes down (demented) and forgetful
-behavioral change, apathy, social w/d -weak, imbalance, ataxia (aphasia, ataxia, apraxia) |
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hyperthyroidism
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-can cause mild cognitive deficits in calculation and recent memory
-tremor -brisk DTR -myalgia and muscle wasting -sensitive to heat |
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hypoglycemic delirium
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-tachycardia
-tremor -hn -seizure |
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triad for MDD
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-feeling ineffectual
-believing world is hostile to her -knowing that things won't change |
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brain changes of schizo
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enlarged ventricles and prominent sulciIED
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brain abnormalities in IED
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-5HT pathway of limbic system
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buproprion required test with nicotine patch
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frequent blood pressure monitoring
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GAD characterized by
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-anxiety about multiple events in conjunction w/ 3 for 6 mo
-impaired sleep -poor concentration -easy fatigue, irritable, muscle tension, restless |