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19 Cards in this Set
- Front
- Back
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For PTSD, what are the two drug mechanisms used
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1. Inhibit NE release
2. Beta blocker |
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For Anxiety, what are the 3 drug mechanisms used
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1. GABA release, hyperpolarization
2. SSRIs 3. Serotonin agonist |
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For anti-depressants, what are 5 drug mechanisms used
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1. TCA
2. SSNRIs 3. SSRIs 4. Selective SSRI's (5-HT1a receptor agonist) 5. MAOIs |
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For bipolar disorder, what are the 2 drug mechanisms
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1. Mood stabilizer - PI inhibitor
2. Anticonvulsants |
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Clonidine
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PTSD
inhibits release of NE -acts at autoreceptors (alpha2 - GPCRs) on presynaptic cell to stop release of NE |
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Propanolol
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PTSD
beta blocker -inhibits NE from interacting with beta-adrenergic receptor on posy-synaptic cell |
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Benzodiazapines
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Anxiolytic
diazapam, alprazolam, midazolam -increase frequency of GABA Cl- channel opening |
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Barbituates
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Anxiolytic
pentobarbital -increase duration of GABA Cl- channel opening -lethal when taken with alcohol (CNS depression) |
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Buspirone
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Anxiolytic
5-HT1a partial agonist |
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Imipramine
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Anti-depressant
TCA - first generation -blocks reuptake of NE and serotonin |
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Nortriptyline
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Anti-depressant
TCA - second generation -blocks reuptake of NE and serotonin |
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Trazodone
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Anti-depressant
TCA - second generation -blocks reuptake of NE and serotonin, mainly at 5-HT2 receptors |
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Bupropion
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Anti-depressant
TCA - 2nd generation -blocks reuptake of NE, serotonin, as well as DOPAMINE |
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Nefazodone
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Anti-depressant
TCA - newer generation -blocks reuptake of NE, serotonin (mainly 5-HT2), and dopamine |
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Duloxetine
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Anti-depressant
SSNRI -blocks reuptake of NE and serotonin |
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Fluoxetine, setraline
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Anti-depressant
SSRI -blocks reuptake of serotonin |
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Phenelzine
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Anti-depressant
MAOI -blocks degradation of NE, serotonin, dopamine |
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Lithium
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Bipolar disease
Mood stabilizer -inhibits PI pathway by decreasing Gq |
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Carbamezapine, valproic acid, lamotrigine
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Bipolar disease
Anti-convulsant -prolong inactivation of Na+ channels -valproic acid and lamotrigine have added benefit of increasing GABA levels to cause hyperpolarization |
