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23 Cards in this Set
- Front
- Back
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Heparin can be neutralized by
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Protamine Sulfate
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Administration route of heparin
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IV or SQ
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IM administration of heparin is avoided due to risk of
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hematoma formation
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Heparins with greater bioavailability and longer duration of action
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LMW heparins - enoxaparin
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Heparan with no cross-hypersensitivity
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Danaparoid
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Heparin and AT III inactivates
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Thrombin (activated factor II) and Factor Xa
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PTT test fails to adequately measure LMW heparin because
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LMW fails to affect thrombin
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Common uses of heparin
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Tx of DVT, PE, and AMI
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Drug of choice for anticoagulants in pregnancy
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Heparin does not cross placental barrier
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Direct thrombin inhibitors
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Lepirudin, bivalirudin, Argatroban
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Alternatives to heparin for patients with HIT
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Lepirudin, argatroban
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Vitamin K dependent clotting factors
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II, VII, IX, X
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Antidote for Coumarin OD
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Vitamin K
Slow recovery FFP Fast recovery |
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Anti-platelet - inhibitors of phosphodiesterase
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Dipyramidole and cilostazol
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Anti-platelet - antagonists of ADP receptors
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ticlopidine and clopidogrel
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Anti-platelet - glycoprotein IIb/IIIa receptor inhibitors
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abciximab, tirofiban, eptifibatide
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Anti-platelet drugs are monitored by
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bleeding time
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MOA of ASA and NSAIDS
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inhibit thomboxane synthesis by blocking the enzyme cyclooxygenase
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MOA of clopidogrel and ticlopidine
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irreversible inhibition of ADP mediated platelet aggregation
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MOA of Plasmin
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splitting fibrin into fragments
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Patients who have had streptococcal infections may have preformed antibodies to
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Streptokinase
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Parenteral vitamin K
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Phytonadione (K1)
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Inhibitors of plasminogen activation
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Aminocaproic acid and tranexamix acid
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