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23 Cards in this Set

  • Front
  • Back
Heparin can be neutralized by
Protamine Sulfate
Administration route of heparin
IV or SQ
IM administration of heparin is avoided due to risk of
hematoma formation
Heparins with greater bioavailability and longer duration of action
LMW heparins - enoxaparin
Heparan with no cross-hypersensitivity
Danaparoid
Heparin and AT III inactivates
Thrombin (activated factor II) and Factor Xa
PTT test fails to adequately measure LMW heparin because
LMW fails to affect thrombin
Common uses of heparin
Tx of DVT, PE, and AMI
Drug of choice for anticoagulants in pregnancy
Heparin does not cross placental barrier
Direct thrombin inhibitors
Lepirudin, bivalirudin, Argatroban
Alternatives to heparin for patients with HIT
Lepirudin, argatroban
Vitamin K dependent clotting factors
II, VII, IX, X
Antidote for Coumarin OD
Vitamin K
Slow recovery

FFP
Fast recovery
Anti-platelet - inhibitors of phosphodiesterase
Dipyramidole and cilostazol
Anti-platelet - antagonists of ADP receptors
ticlopidine and clopidogrel
Anti-platelet - glycoprotein IIb/IIIa receptor inhibitors
abciximab, tirofiban, eptifibatide
Anti-platelet drugs are monitored by
bleeding time
MOA of ASA and NSAIDS
inhibit thomboxane synthesis by blocking the enzyme cyclooxygenase
MOA of clopidogrel and ticlopidine
irreversible inhibition of ADP mediated platelet aggregation
MOA of Plasmin
splitting fibrin into fragments
Patients who have had streptococcal infections may have preformed antibodies to
Streptokinase
Parenteral vitamin K
Phytonadione (K1)
Inhibitors of plasminogen activation
Aminocaproic acid and tranexamix acid