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14 Cards in this Set

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Penicillin
B-lactam
---dont take w/ cephalosporins, Imipenem, Aztreonam

G+ - easy to get to PBPs

Bacteriocidal (actively dividing)
PenG
salt, parenteral, drug of choice

-good distribution
-watch kidney fcn
-allergies, neurotoxic w/ OD
**dont mix w/ aminoglycocides
PenV
oral, w/food is OK
Penicillinase
resistant PCNs
Nafcillin, oxacillin, cloxacillin, dicloxacillin
--MRSA: vanco
Broad Spec Penicillins
aminopenicillins
(ampicillin, amoxicillin)

G-
Extended spectrum
antipseudomonals
(ticarcillin, carbenicillin, piperacillin)

w/ aminoglycosides
ventilator/hospital pts
PCNs combined w/ B-Lactamase inhibitors
augmentin, zosyn (helps w/ some resistance)
allergy
prior exposure needed
-immediate = anaphylaxis
-accelerated = hrs
-late = days/wks
*always stop med
Cephalosporins
4 generations (4th is newest)

B-Lactam antibiotics (so dont give w/ PCNs)

bacteriocidal (dividing bacteria)

low toxicity

resistance - due to b-lactamase
cephalosporins: uses
infection of...
skin
bone
heart
blood
respiratory
GI
GU
cephalosporins: rxns & generations
*allergic rxn w/ PCNs
*adjust dose w/ renal pts (watch BUN & creat)
*ETOH intoll. (n/v, cold sweat)
*anticoag (coumadin), aminoglycocides
-watch for bleeding, bruising, etc.

4th generations better at...
-activity w/ G- and anaerobes
-resistance to destruction by b-lactamase
-ability to reach CSF
Carbapenems
(Imipenem)
**best b-lactam for anerobes
broad spec
**give w/ cilastin
X PCN allergy pts
Parental only
Monobactams
(aztreonam)

G-
**NO activity for G+ or anerobes**
CAN be given to PCN allergic pts
Vanco
staph aureus, MRSA, p. colitis
G+, with aminoglycosides
SAFE for PCN allergic
**red neck syndrome if given too fast
**ototoxic/nephrotexic

Peak - 1 hr after
Trough - before next dose
administer slow!