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5 Cards in this Set
- Front
- Back
Daptomycin
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Lipopeptide class
Bactericidal and Conc dep MOA: Agent binds to the cell membrane of gram+ in a calcium dependent process that disrupts the bacterial cell membrane potential Acts against growing, resting and biofilms Maintains is activity against vancomycin resistent |
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Polypeptide Detergent
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Members include Colstin, Colistimethane and Polymyxin B
These are cyclic cationic polypetide detergents with MW>1000, bactericidal and conc dep MOA: They are surface active amphipathic agents that penetrate into the cell membranes interact with phosholipids in the membrane of gram - bacilli (p. aeruginosa) SE: Nephrotoxicity |
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Colistin
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Polymyxin
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Colistimethane
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Polymyxin
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Polymyxin B
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Polmyxin
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