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5 Cards in this Set

  • Front
  • Back
Daptomycin
Lipopeptide class
Bactericidal and Conc dep
MOA: Agent binds to the cell membrane of gram+ in a calcium dependent process that disrupts the bacterial cell membrane potential
Acts against growing, resting and biofilms
Maintains is activity against vancomycin resistent
Polypeptide Detergent
Members include Colstin, Colistimethane and Polymyxin B
These are cyclic cationic polypetide detergents with MW>1000, bactericidal and conc dep
MOA: They are surface active amphipathic agents that penetrate into the cell membranes interact with phosholipids in the membrane of gram - bacilli (p. aeruginosa)
SE: Nephrotoxicity
Colistin
Polymyxin
Colistimethane
Polymyxin
Polymyxin B
Polmyxin