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7 Cards in this Set

  • Front
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Increase GH
- Alpha-agonists
- L-DOPA
- Amphetamine
Decrease GH
- Beta-agonists
- Phenothiazines
Ocreotide
(Sandostatin)
- synthetic somatostatin agonist
- more selective that somatostatin and has longer half-life
- drug of choice for reducing GH secretion
- used to treat: acromegaly, metastatic carcinoid, VIP secreting tumors, AIDS-related diarrhea
- side effects: hypothyroidism, malabsorption, loose stool, flatulence, nausea
Pegvisomant
(Somavert)
- analog of human GH conjugated to polyethylene glycol
- blocks GH binding to receptor, reduces serum IGF-1, but increase GH
- most effective drug to treat acromegaly
- well tolerated; 17% develop anti-GH Ab that can lead to cardiovascular problem
Bromocriptine
- DA agonist (D2 receptor agonist)
- orally active (bound to serum albumin, excreted mainly in bile)
- used to treat: hyperprolactinemia, acromegaly, Parkinson's disease
- adverse reactions: postural hypotension, headache, dizziness, nausea
- contraindication: sensitivity to any ergot alkaloid (similar structure)
Pergolide
- DA agonist
- used to treat: hyperprolactinemia
- used once a day
Cabergoline
- DA agonist (D2 receptor agonist)
- used to reat: hyperprolactinemia
- longer half life, used only once or twice a week