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7 Cards in this Set
- Front
- Back
Increase GH
|
- Alpha-agonists
- L-DOPA - Amphetamine |
|
Decrease GH
|
- Beta-agonists
- Phenothiazines |
|
Ocreotide
(Sandostatin) |
- synthetic somatostatin agonist
- more selective that somatostatin and has longer half-life - drug of choice for reducing GH secretion - used to treat: acromegaly, metastatic carcinoid, VIP secreting tumors, AIDS-related diarrhea - side effects: hypothyroidism, malabsorption, loose stool, flatulence, nausea |
|
Pegvisomant
(Somavert) |
- analog of human GH conjugated to polyethylene glycol
- blocks GH binding to receptor, reduces serum IGF-1, but increase GH - most effective drug to treat acromegaly - well tolerated; 17% develop anti-GH Ab that can lead to cardiovascular problem |
|
Bromocriptine
|
- DA agonist (D2 receptor agonist)
- orally active (bound to serum albumin, excreted mainly in bile) - used to treat: hyperprolactinemia, acromegaly, Parkinson's disease - adverse reactions: postural hypotension, headache, dizziness, nausea - contraindication: sensitivity to any ergot alkaloid (similar structure) |
|
Pergolide
|
- DA agonist
- used to treat: hyperprolactinemia - used once a day |
|
Cabergoline
|
- DA agonist (D2 receptor agonist)
- used to reat: hyperprolactinemia - longer half life, used only once or twice a week |