Drugs On Boards

Front 1

treat organophosphate overdose?

Back 1

pralidoxime

(too much parasymp cholinesterase inhib)

Front 2

bethanochol

Back 2

act bowel and bladder (post op ileus)

cholinergic agonist

Front 3

carbachol

Back 3

(constrict)
tx mydriasis, glaucoma

cholinergic agonist

Front 4

pilocarpine

Back 4

glaucoma (emergencies), stim sweat, tears, saliva

cholinergic agonist

Front 5

methacholine

Back 5

asthma stim test (BC) dec HR

cholinergic agonist

Front 6

neostigmine

Back 6

anticholinesterase inhibitor

postop ileus, neurogenic ileus; urinary retenion
myathenia gravis

Front 7

pyridostigmine

Back 7

anticholinesterase inhibitor
myathesnia gravis

Front 8

edrophonium

Back 8

anticholinesterase inhibitor
tensilon test for MG

Front 9

physostigmine

Back 9

fixes glacoma BBB, atropine overdose

anticholinesterase inhibitor

Front 10

echothiophate

Back 10

glaucoma

anticholinesterase inhibitor

Front 11

donepezil

Back 11

anticholinesterase inhibitor

alzeimer's (not enough Ach)

Front 12

rivostigmine

Back 12

anticholinesterase inhibitor

alzeimer's (not enough Ach)

Front 13

parasymp excess

Back 13

DUMBBELSS
diarrhea, urination, miosis, brady, BC, excite sk mm, lacrimation, salivaiton, sweat caused by organophosphates

Front 14

antiparasympathetic symptoms

Back 14

bloated as a toad, red as a beet, hot as a hare, dry as a bone, blind as a bat (cycloplegia blurry vision no accomidaiton), mad as a hatter
CI-alzeimer's, glaucoma, BPH, hyperthermia

Front 15

benztropine

Back 15

parkinson's (they have too much Ach)

muscarinic antagonists

Front 16

atropine

Back 16

dilate eye

muscarinic antagonists

Front 17

homatropine

Back 17

dilate eye

muscarinic antagonists

Front 18

tropicamide

Back 18

dilate eye

muscarinic antagonists

Front 19

scopolamine

Back 19

muscarinic antagonists

motion sickness, N/V deep sea fishing

Front 20

ipratropium

Back 20

muscarinic antagonists

asthma COPD

Front 21

oxybutynin

Back 21

muscarinic antagonists

urge incontience for spastic bladder (DO NOT GIVE IN BPH)

Front 22

tropsium

Back 22

muscarinic antagonists

urge incontience for spastic bladder (DO NOT GIVE IN BPH)

Front 23

darifenacin

Back 23

muscarinic antagonists

urge incontience for spastic bladder (DO NOT GIVE IN BPH)

Front 24

solifenacin

Back 24

muscarinic antagonists

urge incontience for spastic bladder (DO NOT GIVE IN BPH)

Front 25

tolterodine

Back 25

muscarinic antagonists

urge incontience for spastic bladder (DO NOT GIVE IN BPH)

Front 26

glycopyrollate

Back 26

muscarinic antagonist

dec airway sec in surgery

Front 27

methscopolamine

Back 27

PUD (dec salivation and acid)

muscarinic antag

Front 28

propanthaline

Back 28

PUD (dec salivation and acid)

muscarinic antag

Front 29

hexamethonium

Back 29

ganglionic blocker, nicotinic antag

BV inhib symp so dec BP, dec CO, dec venous return
HR inhib para dec HR, urinary-para so urinary rtn; GI para so dec motility and digestion; eye para-mydriasis

Front 30

how to make Ach?

Back 30

RLS-->choline + Na inhib by hemicholium
acetyl Coa + choline by ChAT inhib by vesamichol
Ach + Ca allows release inhibited by botulinum increased by black widow toxin
broken down by AchE

Front 31

how to make NE?

Back 31

Phe-->tyrosine +Na
tyrosine hydroxylase makes DOPA inhib by metyrosine
Dopamine (inhib by reserpine)
Nor prevent release by bretillium and guantheidine; stim by ephedrine, amphetamine, tyramine; block reuptake by cocaine, TCAs, tyramine
binds a1b1,b2 inhib a2m2; AT2 sitm
metab by MAO COMT

Front 32

epinephrine

Back 32

agonist a1, a2, b1, b2 low dose b1

anaphylaxis; poss hypovolemia shock because there is more VC to inc BP

if you add phentolamine (a blocker) there is less VC so you actually are dec BP

Front 33

norepinephrine

Back 33

more a1, a2 to VC inc BP
for septic shock which VD but dec renal perfusion
REFLEX BRADY

Front 34

isoproterenol

Back 34

B1=B2 inc HR and dec BP so WIDE PULSE PRESSURE inc systolic dec diastolic
treats brady AV block

Front 35

dopamine

Back 35

D1=D2>B>a agonist
ionotropic and chronotropic; shock and inc renal perfusion treats HF
D1 relaxes renal sm to inc circulaiton
D2 modulates NT

Front 36

dobutamine

Back 36

B1>B2 agonist so inc HR
treats cardiogenic shock to inc contractility
HF
stress test

Front 37

phenylephrine

Back 37

A1>A2 agonist

VC, inc BP papillary dilation, nasal decongestion for nose bleed
phentolamine (a1 blocker) neutralizes

Front 38

metaproterenol

Back 38

B2>B1 agonist
asthma short acting

Front 39

albuterol

Back 39

B2>B1 agonist
asthma short acting

Front 40

salmeterol

Back 40

B2>B1 agonist
asthma long acting

Front 41

terbutaline

Back 41

B2>B1 agonist
asthma AND dec premature uterine contractions

Front 42

ritodrine

Back 42

B2>B1 agonist
dec premature uterine contractions

Front 43

phenoxybenzamine

Back 43

rev a1/a2 blocker
pheochromocytoma
orthostatic HTN, reflex tach
irrev

Front 44

phentolamine

Back 44

rev a1/a2 blocker
pheochromocytoma
orthostatic HTN, reflex tach

Front 45

prazosin

Back 45

a1 blocker
orthostatic HTN 1st dose; dizzy HA
BPH- for urinary rtn

Front 46

phentolamine

Back 46

a1 blocker
used to block epi ect

Front 47

mirtazapine

Back 47

a2
treats depression-->sedation
inc CH, inc appetite

Front 48

timolol

Back 48

BB nonselective; glaucoma

Front 49

acebutolol

Back 49

partial agonist BB

Front 50

esmolol

Back 50

BB IV

Front 51

metoprolol

Back 51

cardioprotective BB

Front 52

propanolol

Back 52

nonselective, treats thyroid storm

Front 53

pindolol

Back 53

partial agonist
BB nonselective

Front 54

2 partial agonist for BB

Back 54

pindolol and acebutolol (one)

Front 55

labetolol

Back 55

nonselective, a1/b2/b1

Front 56

natolol

Back 56

BB; nonselective
dec esophageal varices; portal HTN

Front 57

2 cardioprotective BB

Back 57

metoprolol and carvetilol

dec mortality

Front 58

describe in general BBs

Back 58

treat HTN, angina (dec HR so less O2 consumption)
post MI,
SVT ;antiarrythmics
CHF NOT acute slows progression

toxic: impotence, CV adverse effects like bradycardia, sedation sleep alteration caution in asthmatics and diabetes
COCAINE NO BBs!

Front 59

MONA?

Back 59

give in an MI
morphine, O2, nitrates, aspirin
BB, acei, statin clopidogrel

Front 60

5 categories to treat glaucoma

Back 60

BB-timolol
PG-PGF2a iris discoloration longer eyelashes latanoprost
diurectis--acetazolamide--carbonic anhydrase inhibitor-->ACIDOSIS; mannitol (emergencies)
cholinomimetics-pilocarpine, carbachol, physostigmine, echothiophate
a agonists-epinephrine and BRIMONIDINE

Front 61

aldesleukin

Back 61

IL-2 treats
RCC, Malignant melanoma

Front 62

filgrastin

Back 62

G-CSF bone marrow
like IL-3

Front 63

sargrastim

Back 63

GM-CSF bonemarrow
like IL-3

Front 64

oprelevkin

Back 64

IL-11 TP

Front 65

etanercept

Back 65

TNF-a biologics
RA, psoriasis, ankalosing spondylitis
Fc IgG + TNF RC

do not give if have TB

Front 66

adalimumab

Back 66

TNFa biologic
RA, psoriasis arthritis, ank spond

do not give if have TB

Front 67

infliximab

Back 67

TNFa biologic
RA, psoriadic arhtritis, ank spond
mouse Ab
do not give if have TB

Front 68

treat wrong disease, drug causes rash?

Back 68

ampillin if given for MONO IV

Front 69

ampicillin/amoxicillin treats?

Back 69

gram + and HELPS
HI, e coli, listeria, proteus, salmonella

Front 70

cephalosporins CI, SE MOA

Back 70

PCN like; CI-aminoglycosides
causes a disulfiram rxn; HS rxns

Front 71

aztreonam

Back 71

aminoglycoside imitator BUT can be given in RF
monobactam
treats gram -; no HS rsn can be given w/ PCN

Front 72

imipenam

Back 72

always give w/ cilastin
broad spec; b lactamase resistant
gram +/- mixed infections
seizures
DOC for enterobacter; big guns!

Front 73

meropenam

Back 73

gram + aerobic mixed infections
broad spec; b lactamase resistant
seizures
DOC for enterobacter; big guns!

Front 74

linezolid

Back 74

MRSA, VRE
binds 23s of 50s interacts w/ initiation complex oral

Front 75

aminoglycoside SE

Back 75

NOT ototoxicity, nephrotox, teratongenic

inactivated in acetylation, adenylation, phosphorylation

Front 76

tetracyclines CI, SE

Back 76

phototox, discolor teeth, GI distress

do not give w/ atacids, iron, mg, dairy, preg

Front 77

macrolides treat?

Back 77

PUS
atypical pneumonia, URI, STD

Front 78

chloramphenicol treats?

Back 78

meningitis strep pneumo, HI, neisseria but cephtriaxone is better b/c less SE

Front 79

chloramphenicol SE

Back 79

aplastic anemia-->gray baby syndrome b/c they lack UDP glucuronyl transferase

Front 80

clindamycin treats?

Back 80

anaerobes b fragilis clostridium asp pneumo; narrow spec
MRSA

Front 81

TMP/SMX inhib 2 enzymes

Back 81

dihydrofolate reductase
dihydropteroate synthase

Front 82

TMP/SMX treats?

Back 82

UTI salmonella shigella, PCP pneumo MRSA
NOT preg women

Front 83

nitrofuantoin

Back 83

treats UTI in preg women

Front 84

fluoroquinolones MOA, CI, SE

Back 84

gyrase topo 2
antacids, dairy, caffiene
bones and groans (children arthropathy) tendonitis in adults

Front 85

metronidazole treats?

Back 85

GET GAP on the Metro
Giardia, entamoeba, trich gardenella, aeaerobes, H pylori

Front 86

treats pseudomonas topically

Back 86

polymyxin