• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/17

Click to flip

17 Cards in this Set

  • Front
  • Back
omeprazole - MOA
inhibits H-K ATPase in parietal cells
pantoprazole is a prodrug. where is it activated?
stomach lumen, liver, blood, canalicular space outside parietal cell
by acid in the canalicular space outside parietal cell
side effects of omeprazole
mild GI problems
increased risk pneumonia and possibly hip fractures
MOA cimetidine
block H2 receptor on pariental cell (H2 receptors increase cAMP which increase activity of proton pump)
side effects of ranitidine
mild GI problems mainly
Side effect - gynecomastia
cimetidine
which H2 blocker inhibits cytochrome P450 enzymes
cimetidine
MOA misoprosol
activates EP3 (prostaglandin) receptors on parietal cells (decrease cAMP and proton pump activity) and epithelial cells (increase mucous, bicarb production) in stomach
side effect - lots diarrhea
omeprazole
ranitidine
misoprostol
sucralfate
aluminum hydroxide
magnesium hydroxide
misoprostol and magnesium hydroxide
contraindicated in pregnancy
omeprazole
ranitidine
misoprostol
sucralfate
aluminum hydroxide
magnesium hydroxide
misoprostol
Which drug(s) are used to prevent aspirin or NSAID induced ulcers
misoprostol, PPIs
Clinical use sucralfate -
peptic ulcers, GERD or both
peptic ulcers
Clinical use omeprazole-
peptic ulcers, GERD or both
both
MOA sucralfate
in low pH - forms a gel that coats ulcer
3 drug treatment for H.pylori
PPI and 2 antibiotics
treatment of Zollinger-Ellison syndrome
PPI
4 drug treatment for H.pylori
2 antibiotics, PPI and bismuth