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69 Cards in this Set
- Front
- Back
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Blepharospasm?
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Botox Type A
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Hemifacial Spasm
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Botox Type A
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Cervical Dystonia
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Botox Type A
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Tx for Essential Tremor that works via GABA a receptors?
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Primidone
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What is the best choice for tx of Essential Tremors?
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Propanolol-- no sedation :)
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What Beta 2 receptor antagonist treats Essential Tremors?
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Propanolol
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What is the tx specifically for contralateral limb tremors in Essential tremors?
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Thalamotomy
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What is the tx specifically for refractory tremor of Essential Tremors?
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Deep Brain Stimulus
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What is the drug of choice for chorea in Huntington dx?
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Tetrabenazine
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What is the MOA of Tetrabenazine?
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non-comp inhib. Of monoamine transport into synatpic vesciles, blocks reuptake of dopamine at VMAT2 and D2
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List 3 drugs for Huntington's Dx.
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Chlorpromazine, Baclofen, Tetrabenazine
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MOA of Chlorpromazine?
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DA antagonists
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What should you NEVER give someone w/Huntingtons?
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L-dopa and Bromocriptine
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What drug is given to kids w/Tourettes to decrease their tics?
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Clonidine (Haloperidol or Pimozide if severe)
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What is the tx for ALS?
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Riluzole
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What is the MOA of Riluzole?
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enhances the reuptake of Glutamate by astrocytes and neurons
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List the 2 drugs for Spasticity.
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Baclofen (GABAb agonist); Tizanidine (Alpha 2 & Alpha 1 Adrenergic Agonists)
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What is the drug for symptoms of Restless Leg Syndrome?
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Ropinirole and Fe Supplements
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What is the drug of choice for Migraines and Cluster Headaches?
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Triptans
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What is the MOA of Triptans?
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5HT 1B/1D Agonists
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What are the prophylaxis of Cluster Headaches?
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Verapamil, Lithium Carbonate, Prednisone
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What makes up the "Holy Trinity"?
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Carisoprodol, Alprazolam, Hydrocodone
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What are the 2 drugs of choice for Spasticity?
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Baclofen, Tizanidine
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What type of drug is Tizandine?
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Central Acting muscle relaxant
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What type of drug is Baclofen?
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Gaba B agonists
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What is the contraindication of Baclofen?
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Peptic ulcers
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What is a problem w/ Tizanidine?
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Hepatic Impairment
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What is a Gaba A agonists that can be used for Spasticity?
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Diazepam
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What drug "modulates" the feedback loop for Spacticity?
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Clonidine
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What is muscle relaxant that is a precursor to Meprobamate?
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Carisoprodol
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What are the SE of Carisoprodol?
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drowsy and withdrawal
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What are Cyclobenzapines used for?
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nocturnal muscle spasms
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what are the SE of Cyclobenzapines?
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Drowsy, anticholinergic effx, heart dysrhythmias
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What is a muscle relaxant that is an analog of antihistamines?
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Orphenadrine Citrate
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What are the SE of Orphenadrine Citrate?
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anticholinergic, Aplastic Anemia
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What muscle relaxant inhibits polysynaptic reflexes?
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Methocarbamol
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What are the SE of Metaxalone?
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drowsy, nausea, dizzy
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What txs of Fibromyalgia have a MOA of prevents reuptake?
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Duloxetine, Milnacripan
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What is a tx for Fibromyalgia that prevents NT release?
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Pregabalin
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What are 2 Opioid Anatgonists?
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Naloxone, Naltrexone
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What opioid anagesic is given w/anticholinergic to prevent bradycardia?
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Oxymorphone
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What opioid analgesic has less vomitting, no histamine release and has a less dependent effect on respiratory center?
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oxymorphone
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What Opioid Analgesic has a short half life, decrease in CV effx, but high respiratory center depression?
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Fentalnyl
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Tx for addicts?
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used to be Methadone, now its Bupre
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What are 2 moderate opioid analgesic moderate agonists?
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Codeine, propoxyphene
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What Opioid is given for Dyspnea, pulmonary edema, acute pain, pre-anesthesia, open heart surgery, and to dec. fear of dying?
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Morphine
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Morphine activates what receptors?
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mu receptors
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What are corticosteroids used for w/MS?
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symptomatic management only--shortens symptoms
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What is assoc. w/prevention of MS?
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Vitamin D
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What MS drug resembles myelin and switches Th1 to Th2?
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Glatiramer Acetate
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What are the SE assoc. w/ Glatiramer Acetate?
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injxn site probs and CHEST pains
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What are the SE assoc. w/IFN beta?
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Flu-like symptoms (some have injxn site probs---Betaseron & Rebif)
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What MS drug treats the secondary progressive form of MS and helps w/symptoms?
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Mitoxantrone
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What is the MOA of Mitaoxantrone?
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inhibits abnormal growth & SUPPRESSES B CELLS and T CELLS
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What are some major SE assoc. w/ Mitaoxantrone?
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Bone Marrow Suppression, Cardiac Toxicity, Teratogenic
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What are some moderate SE assoc. w/ Mitaoxantrone?
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increased Liver enzymes, nausea, alopecia
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What MS drug is there a concern w/the lifetime dose given?
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Mitoxantrone
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What MS drug is developing PML a concern BUT this drug jprevents relapses??
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Natalizumab (Tysabri)
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What MS drug is a monoclonal Ab against alpha 4 integrin?
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Natalizumab (Tysabri)
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What MS drug is given for progressive MS and has serious SE?
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Rituximab
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What is the treatment for fatigue assoc. w/ MS?
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Amantidine
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What are the Disease modifying drugs for MS?
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IFN beta 1a, IFN beta 1b, Glatiramer
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What MS drug helps with the spasticity?
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Tizanidine
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What is the MOA of Tizanidine?
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alpha 2 receptor agonists ( increases presynaptic inhibition of motor neurons)
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What MS drug sequesters lymphocytes in the lymph nodes so they can't migrate to the target organ?
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Fingolimod
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What MS drug is a sphingosine 1-phosphate receptor modulator (S1P-R)?
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Fingolimod
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What MS drug is given to manage gait diffuculties (improves walking SPEED)?
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Dalfampridine
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What is the MOA of Dalfampridine?
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K+ channel blocker so there is an increase in axonal conduction
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What is the dose-dependent SE assoc. w/ Dalfampridine?
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Seizures
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