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15 Cards in this Set
- Front
- Back
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Levadopa
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treatment for Parkinson's
Dopamine cannot cross BBB but L-Dopa can, allowing it to go in and get converted |
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Selegeline
Rasagiline |
Tx for Parkinson's
Inhibits MAO and therefore the intracellular degradation of dopamine |
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Amantidine
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Tx for Parkinson's
Stimulates Dopa release and Inhibits synaptic reuptake of dopamine - increasing the concentration at the synapse |
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DA agonists
Pramipexole Ropinirole |
Tx for Parkinson's
obvious ... |
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COMT inhibitors
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Tx for Parkinson's
inhibit the post-synaptic degradation of Dopa |
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Acetylcholine Inhibitors
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Tx for Parkinson's
Block the action of Ach in the striatum The activities of Ach and dopamine are antagonistic - there is a delicate balance in the ganglia that is lost in parkinson's |
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surgical ablation of STN
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Tx for Parkinson's
leads to decreased activation of the inhibitory GPi >>> disinhibition of thalamus |
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surgical ablation of GPi
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leads to disinhibition of thalamus
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deep brain stimulation of GPi or STN
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Tx for Parkinson's
it works really well ... but can lead to rare weakness/paralysis |
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Beta Blockers
Ethanol Deep Brain Stimulation |
All effective treatments for Essential Tremor, a progressive movement disorder with a familial component
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D-penicillamine
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One of several copper chelaters useful in the treatment of Wilson Disease
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Haloperidol
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Tx Tardive Dyskinesia and Tourette
Dopamine receptor blocker. It blocks the dopaminergic action in the nigrostriatal pathways, which is the probable reason for the high frequency of extrapyramidal-motoric side-effects (dystonias, akathisia, pseudoparkinsonism) |
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Aricept
Exelon Reminyl |
Tx: Alzhemier's
Mechanism - AchE inhibitors - not sure how they work but based on the fact that Ach is WAY lower in these pts Works for 1 of 7 patients |
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Memantine
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Tx: Alzheimers (shitty)
Mech: originally made for stroke, but seems to work about half as well as AchE inhibitors for Alzheimers pts |
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Beta and Gamma secretase inhibitors
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Tx: The potential new holy grail for Alzhemiers
Mech: prevent the processing of amyloid ... |
