Drugs For Acne, Rosacea, Scar Therapy And Psoriasis

Front 1

Primary bacteria associated with acne?

Back 1

Propionibacterium acnes

Front 2

Small, pale nodule in acne just beneath skin surface that is a precursor to other lesions?

Back 2

Closed comedo (whitehead)

Front 3

Protrusion of keratin/sebum plug that also contains melanin?

Back 3

Open comedo (blackhead)

Front 4

Mechanism through which Propionibacterium cause acne vulgaris?

Back 4

Secretion of chemicals that break down the wall of the pore, spilling bacteria such as Staphylococcus aureus into the skin and forming an acne lesion (folliculitis).

Front 5

Papule?

Back 5

Small, red acne lesion.

Front 6

Pustule?

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Inflamed whitehead.

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Deep-seated, large, pus-filled and painful acne lesions>

Back 7

Nodule/Cyst

Front 8

Pneumonic for PIMPLE?

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Phenytoin
Isoniazid
Moisturizers
Phenobarbital
Lithium
Ethionamide
Steroids

Front 9

Non-inflammatory acne is marked by?

Back 9

Open and closed comedones.

Front 10

Inflammatory acne is marked by?

Back 10

Papules
Pustules
Nodules
Cysts – cystic acne

Front 11

Mild acne classification?

Back 11

Comedomes with <10 papules/ pustules confined to one area.

Front 12

Moderate acne classification?

Back 12

10-40 comedomes or 10-40 papules/ pustules involving the face and trunk.

Front 13

Moderately severe acne classification?

Back 13

40-100 comedomes or 40-100 papules/ pustules and <5 nodular lesions involving the face, chest and back.

Front 14

When to refer to a physician for acne treatment?

Back 14

Moderate to severe cases or evidence of papules, pustules, nodules, cysts, scarring or potential for scarring or
exacerbating factors or
possible rosacea

Front 15

Non-Pharmacological Acne Treatments?

Back 15

-GENTLY wash affected areas twice daily
-Gentle, Soap-free Cleansers
-Minimize exacerbating factors

Front 16

Pharmacological Treatment Strategies for Acne?

Back 16

-Unblock pilosebaceous ducts
-Decrease sebum production
-Change sebum composition by decreasing bacteria

Front 17

Most drying topical acne treatments?

Back 17

Gels

Front 18

Least drying topical acne treatments?

Back 18

Creams

Front 19

How long should a trial with benzoyl peroxide products last prior to trying other treatments?

Back 19

6-8 weeks, but response can be seen in as little as 5 days.

Front 20

Triaz?

Back 20

Benzoyl peroxide face Wash 9%, cleaning pads (6%)

Front 21

Neutrogena Clear Pore Cleanser?

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3.5% benzoyl peroxide

Front 22

Clearasil Vanishing Acne Treatment?

Back 22

10% benzoyl peroxide

Front 23

Proactiv Repairing Lotion?

Back 23

2.5% benzoyl peroxide

Front 24

Neutrogena On-the-Spot Acne Treatment?

Back 24

2.5% benzoyl peroxide

Front 25

Azelex, Finacea?

Back 25

Azelaic acid: Topical treatment for mild-moderate acne and inflammatory papules.

Front 26

Mechanism of action of azelaic acid?

Back 26

Unknown. Possibly antimicrobial and/or antioxidant.

Front 27

Apparent activity of azelaic acid?

Back 27

Comedolytic, anti-inflammatory, antibacterial

Front 28

Side effects of azelaic acid?

Back 28

Ttransient mild erythema, burning and pruritus. May cause hypo-pigmentation

Front 29

Salicylic Acid products are used for which acne classification?

Back 29

Mild acne.

Front 30

Which OTC acne products contain salicylic acid?

Back 30

-Clearasil Overnight Acne Defense Gel 2%
-Neutrogena Clear Body Wash 2%

Front 31

MOA of Salicylic acid products for acne?

Back 31

Mildly comedolytic, surface keratolytic.

Front 32

Acne products containing a combination of 3-8% sulfur and 2% resorcinol are?

Back 32

Keratolytic

Front 33

Acnomel Cream?

Back 33

-Sulfur 8%, Resorcinol 2%
-(Acne Lotion 10) Sulfur 10% QD-TID

Front 34

Alternative medicine acne products?

Back 34

-Tea tree (Melaleuca alternifolia) oil products
-Supplemental oral zinc product – Zinc gluconate 200mg qd-bid

Front 35

Primary treatment and preventative agent for moderate, mod/severe, and even mild acne when benzoyl peroxide fails?

Back 35

Topical retinoids

Front 36

Tretinoin product for hyperpigmentation and wrinkles ?

Back 36

Renova

Front 37

Acne vulgaris is a disease of the?

Back 37

pilosebaceous unit

Front 38

Adult acne is more prevalent in males or females?

Back 38

Females

Front 39

Inflammatory acne lesions are?

Back 39

Papules, pustules and nodules.

Front 40

Adult acne is more common on the?

Back 40

Jaws and chin

Front 41

Increased sebum in acne is primarily due to?

Back 41

Androgen excess

Front 42

What is the cause of increased sebum production in acne?

Back 42

Hormonal imbalances

Front 43

What causes the pilosebaceous unit to become clogged in acne?

Back 43

Abnormal follicular keratinaztion

Front 44

Benzoyl peroxide products are recommended in combination with topical retinoids for moderate to severe acne, but not with oral retinoids. Why?

Back 44

Oral retinoids are especially drying

Front 45

When should Azelaic acid be used for acne?

Back 45

-for mild acne when the pt. cannot tolerate benzoyl peroxide
-in moderate to severe acne in combination with topical and/or oral antibiotics or topical retinoids

Front 46

Which acne treatment causes sloughing?

Back 46

Salicylic Acid products

Front 47

Name 2 salicylic acid products for acne.

Back 47

-Clearasil Overnight Acne Defense Gel 2%
-Neutrogena Clear Body Wash 2%

Front 48

Corticosteroid used for intra-lesional injection in acne?

Back 48

Triamcinalone

Front 49

Primary treatment and preventative agent for moderate, mod/severe, and even mild acne?

Back 49

Topical Retinoids

Front 50

Maintenance therapy dosing for topical retinoids?

Back 50

Lowest effective concentration at the maximum effective interval.

Front 51

Available concentrations of Retin-A.

Back 51

0.025-0.1%

Front 52

Pregnancy category of topical retinoids?

Back 52

Pregnancy Category C

Front 53

A common regimen for acne treatment would be?

Back 53

-Benzoyl Peroxide cleanser bid
-Tretinoin Gel 0.1% hs
-Clindamycin 1% solution in Pledget bid

Front 54

Differin?

Back 54

Adapalene: Retinoid compound – 0.1% and 0.3%- for mild and mild/moderate acne

Front 55

Tazorac?

Back 55

Tazarotene

Front 56

Synthetic retinoid that affects cell proliferation, differentiation and inflammation? Used in mild to moderate acne.

Back 56

Tazarotene (Tazorac)

Front 57

Tazarotene concentrations and sig?

Back 57

Apply QHS – 0.1% and 0.05% concentrations

Front 58

Doxycycline doses for acne?

Back 58

Initial dose – 100mg po qd or bid
Maintenance dose – 50-100mg QD

Front 59

Doxycycline side effects?

Back 59

Increased photosensitivity

Front 60

Minocycline dose for acne?

Back 60

Usual dose – 50-75-100mg QD or BID
Often begun BID and reduced to QD after 1-2 months

Front 61

Minocycline side effects?

Back 61

Hypersensitivity syndromes, discoloration of skin, bone, nail, cutaneous hyperpigmentation in acne scar areas; rare - SLE

Front 62

Solodyn?

Back 62

Minocycline Extended release

Front 63

Common oral antibiotic used in acne cases where Doxycycline is ineffective or not tolerated.

Back 63

Bactrim

Front 64

Antibiotic not recommended for oral use in acne?

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Clindamycin

Front 65

Erythromycin oral dose for acne?

Back 65

2500-1000 mg per day in divided doses

Front 66

Oral contraceptives used to treat acne in women?

Back 66

Ortho-Tri-Cyclen-Norgestimate and ethinyl estradiol
Estrostep-Norethindrone and ethynyl estradiol
Yasmin, Yaz- Drospirenone and ethinyl estradiol

Front 67

Anti-androgen used only in females for acne?

Back 67

Spironolactone

Front 68

Treatment options for polycystic ovary syndrome (PCOS)?

Back 68

-Oral contraceptives
-Spironolactone
-Metformin 1500-2000mg per day in divided doses

Front 69

Only acne treatment associated with permanent remission?

Back 69

Isotretinoin (Accutane)

Front 70

Accutane dosage forms?

Back 70

10mg, 20mg, 40mg capsules

Front 71

Patient instructions with accutane?

Back 71

Take with food or milk
Protect capsules from light

Front 72

Most common side effects of Accutane?

Back 72

Drying of oral, nasal, optic mucosa
Skin desquamation
Arthralgias, muscle stiffness
Photosensitivity

Front 73

Usual duration of Accutane treatment?

Back 73

6 months, as needed for permanent remission

Front 74

Baseline and Monthly labs required with Accutane treatment?

Back 74

-Lipids
-LFTs
-CBC (neutropenia)

Front 75

Mild Acne but with Papules or Pustules requires the addition of ______to the treatment regimen.

Back 75

Oral or topical antibiotics

Front 76

Treatment for Severe Papulopustular or Nodular Acne?

Back 76

Oral Isotretinoin and wash with soap free cleanser at least bid and prn before and after sweating/exercise
(Oral antibiotics are not used in combination with oral isotretinoin)

Front 77

Sample Treatment Regimen for Mild Acne but with Papules or Pustules.

Back 77

Topical benzoyl peroxide wash bid and topical Clindamycin or Erythromycin bid; wash with a soap free cleanser at least bid prn plusTopical retinoid qhs

Front 78

Chronic inflammatory disorder of the skin that involves blood vessels and pilosebaceous units?

Back 78

Rosacea

Front 79

Type of rosacea with thickened skin with prominent pores?

Back 79

Phymatous

Front 80

Type of rosacea with persistent facial erythema, papules, pustules, flushing, telangiectasias, ocular inflammation?

Back 80

Papulopustular

Front 81

Type of rosacea marked by persistent facial erythema, flushing, telangiectasias and easily irritated facial skin, but no papules or putules?

Back 81

Erythematotelangiectic

Front 82

Least common sub-type of rosacea?

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Phymatous

Front 83

Mainstay of rosacea therapy?

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Metronidazole (example- MetroGel, MetroCream®)

Front 84

Function of metronidazole (metro-gel, metro-cream).

Back 84

Reduction of erythema and inflammatory lesions

Front 85

Common combination therapy for rosacea?

Back 85

-Topical metronidazole qd to bid
-Oral doxycycline (Oracea) 40mg qam
-Soap free cleanser

Front 86

Conditions that may develop with ocular rosacea?

Back 86

blepharitis, sties, episcleritis, keratitis, iritis

Front 87

Tetracycline dose for rosacea?

Back 87

250-500mg bid

Front 88

Doxycycline dose for rosacea?

Back 88

50-100mg qd-bid

Front 89

Minocycline dose for rosacea?

Back 89

50-100mg qd-bid

Front 90

Oracea?

Back 90

Doxycycline: 40mg ( 30mg immediate release and 10mg delayed release) – one qam

Front 91

Major types of mature scars?

Back 91

Keloid
Hypertrophic
Acne related

Front 92

Type of scar characterized as raised and red?

Back 92

Minor keloid

Front 93

Dark red, raised scar with increased pigmentation compared to natural skin color.

Back 93

Major keloid

Front 94

Raised scar within boundaries of original injury?

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Hypertrophic

Front 95

Scar therapy that mimics epithelium?

Back 95

silicone sheeting

Front 96

Wound healing stages?

Back 96

-Inflammation
-Proliferation
-Remodeling

Front 97

Scars are formed during which stage of wound healing?

Back 97

Remodeling

Front 98

MOA of silicone sheeting in scar therapy?

Back 98

hydration and occlusion

Front 99

Mederma skin care gel?

Back 99

Onion extract - Allium cepa - Cepalin®- active ingredient - quercetin
Conclusive Studies scarce

Front 100

Mederma sig?

Back 100

New scars- TID x 8 weeks
Existing scars- TID x 3-6 months

Front 101

MOA of pressure garments in scar therapy?

Back 101

Decrease excessive collagen deposits

Front 102

Corticosteroid for Intra-lesional injection in scar therapy?

Back 102

Triamcinalone

Front 103

Mainstay of therapy for mature scars?

Back 103

Triamcinalone injections

Front 104

Other injectable for mature scar therapy?

Back 104

5-Fluorouracil (5-FU)

Front 105

MOA of 5-Fluorouracil (5-FU)

Back 105

Antimetabolite: Targets rapidly proliferating cells

Front 106

Kelo-cote?

Back 106

Silicone gel: QD-BID application,
60-90 days use recommended. For most scar types.

Front 107

Role of topical vitamin-E in scar therapy?

Back 107

Questionable efficacy, use in mature scars only as it may cause wound separation.

Front 108

Scar Guard Scar Care?

Back 108

Liquid formula (Vit. E, silicone, cortisone): Provides a film cover,
BID application x 2-4 months.

Front 109

OTC product for thick, overgrown scars?

Back 109

Scar Guard Scar Care

Front 110

ScarFx

Back 110

Silicone elastomer sheet, hypoallergenic tape for hypertrophic and keloid scars. Apply QD x 12-24 hours, 8-12 weeks

Front 111

Neosporin Scar Solution?

Back 111

Silicone scar sheets. Apply sheet to affected area; leave on at least 12 h and up to 3 days and use for 12 weeks

Front 112

OTC scar product for post-inflammatory hyperpigmentation in Non-Keloid scars?

Back 112

Hydroquinone

Front 113

Products containing hydroquinone?

Back 113

ScarGuard Lightener
Alpha Hydrox Fade Cream
Esoterica (with SPF)
Porcelana