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30 Cards in this Set
- Front
- Back
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u k |
on the membrane |
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delta |
inside the cell |
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opiate receptors only work in the |
presynaptic |
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opiates bind to "u" in the |
gaba neuron in the VTA and inhibits it. more dopamine secretion |
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Chronic use of morphine |
increasing AC and PKA synthesis->3meedot. |
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if you stop using morphine after chronic |
high CAMP+PKA!! locus serelium VTA->DEPRESSION high adrenaline+gaba activity |
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thalamus and brain stem |
tloot - symptoms when u stop using it |
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reward mesolimbic |
addiction |
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טיפול אחזקה |
methadone... more oral availaibility less euphoria... neeged tesmone gmela |
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on the VTA there are gaba and kappa receptors |
gaba works on gaba and inhibits Dynorphin works on kappa and inhibits |
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cocaine side effects |
mydriasis tachycardia puking weak muscles belbool |
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תסמונת גמילה של קוקאין |
רק נפשית יותר קשה דיקאון חוסר תאבון חוסק שינה 24 שעות 7 ימין |
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Reward pathway |
VTA, nucleus accumbens,caudate nucleus |
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striatum (caudate nucleus) |
motor |
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cocaine goes |
to all brain parts but only binds to specific parts striatum and VTA + nucleus accumebns |
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How does cocaine works |
itblocks the reuptake of dopamine in the dopaminergic terminals-> raises dopamine in the cleft. |
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cocaine raises |
motor acitivity |
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if you take cocaine after gmeela you get |
same intensity |
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Important:Drugs raises dopamine that binds to |
NAc->camp raises ->CREB->dyonrphin |
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Dyonrphin genes increase |
only by chronic use on drugs |
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neurons terminals after chronic drug use |
are larger ( less tolerance) |
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Hallucinogen |
Ecstasy LSD Marijuana
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active in grass |
THC JOIN OR SWALLOW |
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whats grass good for |
against vomitting in cancer(dronabinol) |
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THC side effects |
dryness in mouth tachycardia |
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THC binds in |
campus,hypocampus,cerrebelum |
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THC binds to |
CB1,CB2(peripheral) |
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CB1 |
reward system,cerrebelum,hypocampus endocannabinoid(endogenic)-andamide |
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CB1+CB2 ARE |
GPCR->gi->less camp |
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THC---> |
less gaba secretion->more dopamine |
