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51 Cards in this Set
- Front
- Back
mechlorethamine?
Which formualtion caused more contact dermatitis? |
Topical nitrogen mustard, or mechlorethamine, is an antineoplastic agent which works via alkylation thereby inhibiting DNA synthesis. Allergic contact dermatitis occurs in two-thirds of patients who are treated with topical nitrogen mustard in aqueous solution, but occurs in less than 5% of patients treated with the ointment based preparation.
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Increase MTX levels
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Displacement of Plasma Proteins:
1. Tetracyclines 2. Phenytoin 3. Pehnothiazines 4. Chloramphenicol 5. NSAIDs 6. Salicylates 7. Sulfonamides |
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AGEP
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cepahlosporins
mercury |
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CREAM
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SEMISOLID EMULSION OF OIL AND WATER
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gel
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semisolid emulsion
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lotion
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liquid aqueous or alcohol based and salt solution
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ointment
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semisolid grease/oil w powder
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paste
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ointment with powder
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mc side effect of imuran
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bm suppression
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malathion
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organophosphate cholinesterase inhibitor
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what medication with imuran will lower IUD effectiveness
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motrin
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Fomiversen
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anti-sense antivirals
CMV retinits w AIDS mc side effects occular inflammation and increase intraocular pressure |
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Sulsobenzone
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sunscreen
UVA blocker |
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Alefacept
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human LFA-3/IgG Fusion protein blocks LFA-3 on APC and CD-2 on T cell
prevents T cell stimulation destroys activated memory T cells |
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2-mercptoethanesulfonate
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MENSA
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Ivermectin FDA approved? MOA?
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FDA-approved for the treatment of strongyloides and onchocerciasis.
blocks glutamate-gated chloride ion channels worm or mite nerve and muscle paralysis |
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SCLE
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piroxicam
glyburide |
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dapsone MOA?
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inhibits halide-myeloperoxidase system
impaired respiratory burst and tissue damage |
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class B
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no risk to humans, may have risk to animals
or no risk to animals, but no studies on humans |
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thalidomide peak toxicity GA?
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21-36 days
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aquired brachia dyschromatosis
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ACE inhibitors
asymptomatic gray-brown pathces with geographic borders w hypopigmented macules on dorsum forearms bilateral, middle age women |
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1,4 dihydroxybenzene
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hydroquionone
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Gold
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stomatitis
chelitis LP PR |
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Thio-TEPA
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alkylating agent
pruritus, urticaria, angioedema, hyperpigmenation occluded areas |
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Busulfan
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Addison's like hyperpigmentation
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Hyperpigmentation teeth with discoloration at the gingival margins
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cyclophosphamide
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Intense flushing
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dacarbazine
carmustine |
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alternating colors of hair
flag sign |
MTX
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drug induced SLE
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isonaizid
penicillamine anticonvulsants |
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Catagory X drugs
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finasteride
5-FU flutamide MTX stanozolol thalidomide |
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silymarin
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antioxidant
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retinoids keratinocyte differentiation
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increase KH granules
increase Filaggrin Increase KIF Increase Odland body secretion of lipids Inhibit ornithine decarboxylase |
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Thiabendazole
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inhibits fumarate reductase
cutaneous larva migrans larva currens |
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Lindane
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organochloride
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peremethrin
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disbles sodium transport channels
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podophyllotoxin
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podofilox or condolox
anti-mitotic agent reversibly binds tubulin metaphase podophyllin same MOA but contains kaempero and quercetin potent mutagens |
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Cantharin
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phosphodiesterase inhibitor
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cellcept binds?
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iron
do not take cellcept with iron, decrease absorption |
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penile calcification
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Bleomycin
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glucocorticosteroids MOA
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decrease AP-1, NF-kB
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most likely congenital defect with isotretinoin therapy?
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cranial synostosis
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P450 metabolized
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carbamazepine
theophylline warfarin digoxin methylprednisolone |
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methyl antranilate
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UVA
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Padimate O
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PABA derivateive
UVB |
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creams
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oil in water
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gels
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semisolid emulsion in alcohol base
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lotions/solutions
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powder in water
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foams
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liquid and or solid in gaseous material
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bacitracin
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polypeptide antibotic
Tracy stain of Bacillus subtilis inhibits bacterial cell wall sytnehsis by complexing with carrier protein C55-prenol pyrophosphatase involved in transfer of polysaccharides, liposaccharides, and peptidoglycans |
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most dramatic decrease in bone density with corticosteroids
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young men
trabecular bone ribs and vertebrae > corticol long bones most demineralization first 6 -12 mths |
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DACTINOMYCIN
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ACUTE SUPERFICIAL FOLLICULITIS OF FACE AND TRUNK
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