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11 Cards in this Set
- Front
- Back
actinomycin D
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Intercalates minor groove of DNA, interfering w/ replication and transcription.
Anticancer |
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5-fluorouracil
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Prevents synthesis of thymine bases, therefore inhibiting DNA replication. Arrests cell cycle in S phase. Anticancer drug.
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Zidovudine (AZT)
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Thymidine analog. Blocks reverse transcriptase activity and inhibits mitochondrial DNA replication. Antiviral drug (HIV)
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Rifampin
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Inhibits prokaryotic RNA polymerase. Antibiotic (tuberculosis)
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Tamoxifen
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Estrogen antagonist. Blocks estrogen receptors, preventing their transcription activating mechanisms. Anticancer (breast)
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Streptomycin
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Binds small (30S) ribosomal subunit in bacteria, blocking formation of initiation complex for translation. Antibiotic.
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Tetracyclin
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Binds small (30S) ribosomal subunit in bacteria, preventing binding of aa-tRNAs. Antibiotic.
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Chloramphenicol
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Inhibits peptidyltransferase activity of large (50S) subunit in bacterial ribosomes. Antibiotic.
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Erythromycin
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Binds large (50S) ribosomal subunits in bacteria, preventing translocation along mRNA. Antibiotic.
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Etoposide
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Inhibits eukaryotic type II topoisomerase, thus preventing unwinding of chromatin and arrest of mitosis. Anticancer.
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Sertraline hydrochloride
(Zoloft) |
Selective serotonin uptake inhibitor (SSRI). Antidepressant.
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