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65 Cards in this Set
- Front
- Back
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Aspirin |
Reduced synthesis of mediators of pain/fever/ inflammation - Can induce asthma Inhibits both types of COX |
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Morphine |
Used for pain |
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Phenylephrine (PE) |
α1-adrenoceptor agonist |
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Clonidine |
α2-adrenoceptor |
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Isoprenaline |
β-adrenoceptor (non-selective) agonist |
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Dobutamine |
Β1 adrenoceptor agonist |
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Salbutamol S3 |
β2 adrenoceptor agonist, Useful in asthma |
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Phentolamine |
A-adrenoceptor |
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Prazosin |
α1-adrenoceptor useful in hypertension |
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Propranolol |
B- Adrenoceptor Useful in hypertension |
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Atenolol |
Β1-adrenocptor antagonist, Useful in hypertension |
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Cocaine |
Inhibit neuronal high affinity uptake 1 of NA Prolong synapse byNA across synapticjunction
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Botulinum Toxin (BoTox) |
Inhibit release of ACh vesicle into synapticjunction cleaves specific SNARE protein Treat Blepharospasm |
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Physostigmine |
Selective for parasympathetic junction, used to treat glaucoma |
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Neostigmine |
Selective for neuromuscular junction Treat Myasthenia gravis |
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Atropine |
(Musantagonist) Anti-SLUD |
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d-tubocurarine |
Nic Antagonist Neuromuscular blocking agent: treat surgical paralysis Competitive reversible antagonist: block reversed with neostigmine |
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Hexamethonium (S4) |
Nicotinic receptor antagonist, both parasympathetic/ sympathetic ganglia Ganglion Blocking drug |
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Penicillin |
observation in lab treat streptococcus |
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Sulphonamides |
Discovery of Sulphonamides(serendipity) antibacterial activity |
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tetracyclines |
Discovery of tetracyclines(screening) antibiotic activity |
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LSD |
Discovery of LSD (syntheticchemistry) hoped for circulatory/circulatory stimulant,uterotonic, made unconscious animals “restless”- absorbed through skin, extremely potent - Complete transformation of “inner and outer worlds” - Perfect recollection |
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Thalidomide |
Treatment of morning sickness cytotoxic to early limb bud cells |
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Cimetidine |
gastric ulcer treatment |
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Zanamivir (S4) |
an anti influenza drug not active following oral administration, needs to be given very early in infection Neuraminidase inhibitors, Neuraminidase helps newly-formed virus to escape cells |
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imatinib |
Use for chronic myeloid leukaemia (CML): slowprogression of CML |
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Zafirlukast, Montelukast |
Cysteinyl leukotriene receptor antagonists |
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Formoterol |
Long-acting β2-adrenoceptor agonists, long onset |
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Salmeterol |
Long-acting β2-adrenoceptor agonists, slow onset |
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salbutamol, Terbutaline |
Short acting β2-adrenoceptor agonists |
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budesonide & fluticasone propionate |
Inhalation administration of Glucocorticoids |
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prednisolone |
Oral administration of Glucocorticoids |
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Glyceryl trinitrate(GTN) |
Prodrug treatment for Angina pectoris |
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Prazosin |
Decrease sympathetic effects on arteries, for hypertension |
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Losartan |
Angiotensin II receptor antagonist, for hypertension |
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captopril &enalapril |
Angiotensin Coverting Enzyme) inhibitors |
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nifedipine |
L-type Ca2+ antagonist |
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disodium cromoglycate |
↓ mast cell mediator release?(Lecture 19) |
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anti-histamines |
decrease actions of mast cell products |
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omaluzimab |
prevent IgE binding to mastcells? |
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Natalizumab |
can be used to prevent rolling |
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Non-steroidal anti-inflammatorydrugs (NSAIDs) |
treat Rheumatoid arthritis |
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Celecoxib |
An example of Non-steroidal anti-inflammatorydrugs (NSAIDs) in RA |
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Cyclosporin |
treat graft rejection |
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ethinyloestradiol |
synthetic oestrogen(Lecture 20) |
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norethisterone drospirenone |
synthesised progesterone |
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Methylphenidate (Ritalin) |
increases synaptic concentration of Dopamine andNoradrenaline by blocking their re-uptake.(lecture 21) |
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Modafinil (Provigil) |
mediate ACh and α1- adrenoceptor activity |
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Amitriptyline |
an example of tricyclic antidepression |
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Fluoxetine |
an example of selective serotonin Re-uptake inhibitors |
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Moclobemide |
an example of reversible monoamine oxidase A inhibitors |
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Lithium Carbonate |
mood stabiliser, can be used to treat bipolar affective disorder |
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morhpine |
analgesia , euphoria(lecture 22) |
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heroin |
analgesia |
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methadone |
used for treatment of opioid dependence |
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naloxone |
Treat opioid overdose |
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codeine |
Antitussive at sub-analgesic doses |
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Fentanyl |
suitable for incident or procedure-related pain |
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Sibutramine & Rimonabant |
2 kinds of obesity drugs that have been banded(lecture 23) |
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Phentermine |
Obesity drug, ↑ NA |
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orlistat |
Obesity drug, Inhibits gastric and pancreatic lipases→↓Dietary fat absorption |
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Liraglutide |
an example of synthetic glucagon-like peptide-1 |
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Anabolic-androgenic steroids(androgen) |
Drug used in sport, an example of anabolic agent(Lecture 24) |
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EPO |
Drug used in sports, protein growth factor |
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AmphetamineMethamphetamine |
examples of stimulant used in sports |
