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118 Cards in this Set

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Drugs
Class of drugs
Mechanism of Action
Theophylline
Phosphodiesterase inhibitors
Caffeine
Papeverine
Sildenafil
Acetazolamide
Drugs used to change urinary pH
Ammonium chloride
Botulinum toxin
Affect Ach release
"1) After binding to a surface protein and being transported into cholinergic neurons by endocytosis, the light chain of the toxin exhibits protease activity.
(Miochol)"
Cholinergic agonists (quaternary compounds)
IV exhibits mainly muscarinic effects; nicotnic actions are only seen after muscarinic receptors have been blocked by atropine (ie. Increases BP and heart rate by stimulating N1-cholinergic receptors at sympathetic ganglia)
(Provocholine)"
Muscarinic receptor agonist
(Carbamylcholine)"
Nicotinic and muscarinic agonist
(Urecholine)"
Muscarinic agonist with a selective effect on the GI and GU tracts
Succinylcholine
Specificity for N2-cholinergic receptors found at the neuromuscular junction of skeletal muscle; depolarizes the motor endplate of skeletal muscle by mimicing the agonist action of Ach --> flaccid paralysis of skeletal muscle (noncompetitive blockade)
(Pilocar, Isopto Carpine)"
"Tertiary amine
(Evoxac)"
Synthetic muscarinic agonist
Pilocarpine
Treatment of glaucoma
"Increase aqueous outlfow: contraction of the meridional fibers of the ciliary muscle increases the iridiocorneal angle and/or the tone and alignment of the trabeculae allowing aqueous humor to flow more easily into the Canal of Schlemm
Betaxolol
"Decrease aqueous humor production
Timolol
(Xalatan)"
"Increase uveoscleral outlflow
Epinephrine
"Increase aqueous outflow via normal, pressure-dependent pathway
Dipivefrin
and brimonidine (Alphagan)"
"Decrease aqueous humor production
Acetazolamide
"Decrease aqueous humor production
Dorzolamide
(Floropryl)"
"Increases aqueous humor outflow
(Phospholine)"
(Osmitrol)"
Given IV; does not leave the extracellular fluid volume; hyperosmolar extracellular fluid causes cellular dehydration--> fall in IOP
Donepezil
Neostigmine
Pyridostigmine
Edrophonium
Carbaryl
Dimpylate
Organophosphate Achase inhibitors
Isofluophate
Parathion
Malathion
Echothiophate
Pralidoxime
Tx of OP poisoning
Atropine
Muscarinic receptor antagonists (Tertiary)
Scopolamine
Cyclopentolate
Tropicamide
Benztropine
Trihexyphenidyl
Dicyclomine
Hyoscyamine
Oxybutynin
Tolterodine
Solifenacin
Darifenacin
Diphenhydramine
N-methylatropine
Muscarinic receptor antagonists (Quaternary)
Methscopolamine
Ipratropium
Glycopyrrolate
Propantheline
Trospium
Nicotine
Nicotinic receptor antagonists
Succinylcholine
Drugs
Class of drugs
Mechanism of Action
Theophylline
Phosphodiesterase inhibitors
Caffeine
Papeverine
Sildenafil
Acetazolamide
Drugs used to change urinary pH
Ammonium chloride
Botulinum toxin
Affect Ach release
"1) After binding to a surface protein and being transported into cholinergic neurons by endocytosis, the light chain of the toxin exhibits protease activity.
(Miochol)"
Cholinergic agonists (quaternary compounds)
IV exhibits mainly muscarinic effects; nicotnic actions are only seen after muscarinic receptors have been blocked by atropine (ie. Increases BP and heart rate by stimulating N1-cholinergic receptors at sympathetic ganglia)
(Provocholine)"
Muscarinic receptor agonist
(Carbamylcholine)"
Nicotinic and muscarinic agonist
(Urecholine)"
Muscarinic agonist with a selective effect on the GI and GU tracts
Succinylcholine
Specificity for N2-cholinergic receptors found at the neuromuscular junction of skeletal muscle; depolarizes the motor endplate of skeletal muscle by mimicing the agonist action of Ach --> flaccid paralysis of skeletal muscle (noncompetitive blockade)
(Pilocar, Isopto Carpine)"
"Tertiary amine
(Evoxac)"
Synthetic muscarinic agonist
Pilocarpine
Treatment of glaucoma
"Increase aqueous outlfow: contraction of the meridional fibers of the ciliary muscle increases the iridiocorneal angle and/or the tone and alignment of the trabeculae allowing aqueous humor to flow more easily into the Canal of Schlemm
Betaxolol
"Decrease aqueous humor production
Timolol
(Xalatan)"
"Increase uveoscleral outlflow
Epinephrine
"Increase aqueous outflow via normal, pressure-dependent pathway
Dipivefrin
and brimonidine (Alphagan)"
"Decrease aqueous humor production
Acetazolamide
"Decrease aqueous humor production
Dorzolamide
(Floropryl)"
"Increases aqueous humor outflow
(Phospholine)"
(Osmitrol)"
Given IV; does not leave the extracellular fluid volume; hyperosmolar extracellular fluid causes cellular dehydration--> fall in IOP
Donepezil
Neostigmine
Pyridostigmine
Edrophonium
Carbaryl
Dimpylate
Organophosphate Achase inhibitors
Isofluophate
Parathion
Malathion
Echothiophate
Pralidoxime
Tx of OP poisoning
Atropine
Muscarinic receptor antagonists (Tertiary)
Scopolamine
Cyclopentolate
Tropicamide
Benztropine
Trihexyphenidyl
Dicyclomine
Hyoscyamine
Oxybutynin
Tolterodine
Solifenacin
Darifenacin
Diphenhydramine
N-methylatropine
Muscarinic receptor antagonists (Quaternary)
Methscopolamine
Ipratropium
Glycopyrrolate
Propantheline
Trospium
Nicotine
Nicotinic receptor antagonists
Succinylcholine