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118 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
Drugs
|
Class of drugs
|
Mechanism of Action
|
|
|
Theophylline
|
Phosphodiesterase inhibitors
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Caffeine
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Papeverine
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Sildenafil
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Acetazolamide
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Drugs used to change urinary pH
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Ammonium chloride
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Botulinum toxin
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Affect Ach release
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"1) After binding to a surface protein and being transported into cholinergic neurons by endocytosis, the light chain of the toxin exhibits protease activity.
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(Miochol)"
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Cholinergic agonists (quaternary compounds)
|
IV exhibits mainly muscarinic effects; nicotnic actions are only seen after muscarinic receptors have been blocked by atropine (ie. Increases BP and heart rate by stimulating N1-cholinergic receptors at sympathetic ganglia)
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(Provocholine)"
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Muscarinic receptor agonist
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(Carbamylcholine)"
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Nicotinic and muscarinic agonist
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(Urecholine)"
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Muscarinic agonist with a selective effect on the GI and GU tracts
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Succinylcholine
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Specificity for N2-cholinergic receptors found at the neuromuscular junction of skeletal muscle; depolarizes the motor endplate of skeletal muscle by mimicing the agonist action of Ach --> flaccid paralysis of skeletal muscle (noncompetitive blockade)
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(Pilocar, Isopto Carpine)"
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"Tertiary amine
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(Evoxac)"
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Synthetic muscarinic agonist
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Pilocarpine
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Treatment of glaucoma
|
"Increase aqueous outlfow: contraction of the meridional fibers of the ciliary muscle increases the iridiocorneal angle and/or the tone and alignment of the trabeculae allowing aqueous humor to flow more easily into the Canal of Schlemm
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Betaxolol
|
|
"Decrease aqueous humor production
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Timolol
|
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(Xalatan)"
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"Increase uveoscleral outlflow
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Epinephrine
|
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"Increase aqueous outflow via normal, pressure-dependent pathway
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Dipivefrin
|
|
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and brimonidine (Alphagan)"
|
|
"Decrease aqueous humor production
|
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Acetazolamide
|
|
"Decrease aqueous humor production
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Dorzolamide
|
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(Floropryl)"
|
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"Increases aqueous humor outflow
|
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(Phospholine)"
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(Osmitrol)"
|
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Given IV; does not leave the extracellular fluid volume; hyperosmolar extracellular fluid causes cellular dehydration--> fall in IOP
|
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Donepezil
|
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Neostigmine
|
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Pyridostigmine
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Edrophonium
|
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Carbaryl
|
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Dimpylate
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Organophosphate Achase inhibitors
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Isofluophate
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Parathion
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Malathion
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Echothiophate
|
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Pralidoxime
|
Tx of OP poisoning
|
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Atropine
|
Muscarinic receptor antagonists (Tertiary)
|
|
|
|
Scopolamine
|
|
|
|
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Cyclopentolate
|
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|
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Tropicamide
|
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Benztropine
|
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Trihexyphenidyl
|
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Dicyclomine
|
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Hyoscyamine
|
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Oxybutynin
|
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Tolterodine
|
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Solifenacin
|
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|
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Darifenacin
|
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Diphenhydramine
|
|
|
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N-methylatropine
|
Muscarinic receptor antagonists (Quaternary)
|
|
|
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Methscopolamine
|
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Ipratropium
|
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Glycopyrrolate
|
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|
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Propantheline
|
|
|
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Trospium
|
|
|
|
|
Nicotine
|
Nicotinic receptor antagonists
|
|
|
|
Succinylcholine
|
|
|
|
|
Drugs
|
Class of drugs
|
Mechanism of Action
|
|
|
Theophylline
|
Phosphodiesterase inhibitors
|
|
|
|
Caffeine
|
|
|
|
|
Papeverine
|
|
|
|
|
Sildenafil
|
|
|
|
|
Acetazolamide
|
Drugs used to change urinary pH
|
|
|
|
Ammonium chloride
|
|
|
|
|
Botulinum toxin
|
Affect Ach release
|
"1) After binding to a surface protein and being transported into cholinergic neurons by endocytosis, the light chain of the toxin exhibits protease activity.
|
|
|
(Miochol)"
|
Cholinergic agonists (quaternary compounds)
|
IV exhibits mainly muscarinic effects; nicotnic actions are only seen after muscarinic receptors have been blocked by atropine (ie. Increases BP and heart rate by stimulating N1-cholinergic receptors at sympathetic ganglia)
|
|
|
(Provocholine)"
|
|
Muscarinic receptor agonist
|
|
|
(Carbamylcholine)"
|
|
Nicotinic and muscarinic agonist
|
|
|
(Urecholine)"
|
|
Muscarinic agonist with a selective effect on the GI and GU tracts
|
|
|
Succinylcholine
|
|
Specificity for N2-cholinergic receptors found at the neuromuscular junction of skeletal muscle; depolarizes the motor endplate of skeletal muscle by mimicing the agonist action of Ach --> flaccid paralysis of skeletal muscle (noncompetitive blockade)
|
|
|
(Pilocar, Isopto Carpine)"
|
|
"Tertiary amine
|
|
|
(Evoxac)"
|
|
Synthetic muscarinic agonist
|
|
|
Pilocarpine
|
Treatment of glaucoma
|
"Increase aqueous outlfow: contraction of the meridional fibers of the ciliary muscle increases the iridiocorneal angle and/or the tone and alignment of the trabeculae allowing aqueous humor to flow more easily into the Canal of Schlemm
|
|
|
Betaxolol
|
|
"Decrease aqueous humor production
|
|
|
Timolol
|
|
|
|
|
(Xalatan)"
|
|
"Increase uveoscleral outlflow
|
|
|
Epinephrine
|
|
"Increase aqueous outflow via normal, pressure-dependent pathway
|
|
|
Dipivefrin
|
|
|
|
|
and brimonidine (Alphagan)"
|
|
"Decrease aqueous humor production
|
|
|
Acetazolamide
|
|
"Decrease aqueous humor production
|
|
|
Dorzolamide
|
|
|
|
|
(Floropryl)"
|
|
"Increases aqueous humor outflow
|
|
|
(Phospholine)"
|
|
|
|
|
(Osmitrol)"
|
|
Given IV; does not leave the extracellular fluid volume; hyperosmolar extracellular fluid causes cellular dehydration--> fall in IOP
|
|
|
Donepezil
|
|
|
|
|
Neostigmine
|
|
|
|
|
Pyridostigmine
|
|
|
|
|
Edrophonium
|
|
|
|
|
Carbaryl
|
|
|
|
|
Dimpylate
|
Organophosphate Achase inhibitors
|
|
|
|
Isofluophate
|
|
|
|
|
Parathion
|
|
|
|
|
Malathion
|
|
|
|
|
Echothiophate
|
|
|
|
|
Pralidoxime
|
Tx of OP poisoning
|
|
|
|
Atropine
|
Muscarinic receptor antagonists (Tertiary)
|
|
|
|
Scopolamine
|
|
|
|
|
Cyclopentolate
|
|
|
|
|
Tropicamide
|
|
|
|
|
Benztropine
|
|
|
|
|
Trihexyphenidyl
|
|
|
|
|
Dicyclomine
|
|
|
|
|
Hyoscyamine
|
|
|
|
|
Oxybutynin
|
|
|
|
|
Tolterodine
|
|
|
|
|
Solifenacin
|
|
|
|
|
Darifenacin
|
|
|
|
|
Diphenhydramine
|
|
|
|
|
N-methylatropine
|
Muscarinic receptor antagonists (Quaternary)
|
|
|
|
Methscopolamine
|
|
|
|
|
Ipratropium
|
|
|
|
|
Glycopyrrolate
|
|
|
|
|
Propantheline
|
|
|
|
|
Trospium
|
|
|
|
|
Nicotine
|
Nicotinic receptor antagonists
|
|
|
|
Succinylcholine
|
|
|
