Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
Hydroxyurea mechanism
|
Inhibits ribonucleotide reductase (down deoxyribunleotides)
|
Sickle cell (increase HbF), melanoma, CML (bone marrow suppression)
|
|
|
6-MP mechanism
|
Blocks de novo purine synthesis (down dAMP and dGMP)
|
Leukemia, lymphomas (non-CLL or Hodgkins), bone marrow, GI liver tox
Metab by xanthine oxidase (increase tox w/ allopurinol) |
|
|
5-FU mechanism
|
Blocks thymidylate synthase (down dTMP)
|
Colon cancer, solid tumors, basal cell carcinoma (topical), used w/ MTX
Rescue w/ thymidine |
|
|
Methotrexate
|
Blocks DHF reductase (down dTMP)
Folic acid analogue |
Leukemia, lymphoma, sarcoma, abortion, ectopic pregnancy, RA, psoriasis
Myelosupresssion, reversible w/ leucovorin (folinic acid) rescue |
|
|
Trimethoprim mechanism
|
Blocks Bacterial DHF reductase (down dTMP)
|
UTIs, Enterics (Shigella, salmonella, pneumosystis jirovei pneumonia)
Megaloblastic anemia, leukopenia, granulocytopenia, can rescue w/ folinic acid (leukovorin) |
