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20 Cards in this Set
- Front
- Back
Drug treatment
-Iron toxicity: -Bone marrow deficiency: |
Deferoxamine
Colony stimulating factors (G-CSF) |
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Where are the hemoprotien receptors located?
-Act as a sensor for O2 |
peritubular cells of the kidney
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Is there ever free iron in the circulatory system?
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Never, always bound
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Inadequate diet (animal proteins, ascorbic acids), and alcoholism may result in this deficiency:
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Iron deficiency
-Associated with increased risk of infection and developmental delays |
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Iron dectran, socium ferric gluconate complex, and iron sucrose are given to the patient how?
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Parentally, IV/IM
-patients with absorptions syndromes or intolerant to iron preps |
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Arthralgias, myalgias, flushing malaise
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Adverse effects of iron supplement
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With what combination must megaloblastic anemia be treated:
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B12 + folic acid combo
-treating B12 defic. with only folic acid can mask the symptoms of the deficiency and cause irreversible damage to the patient's neurological system |
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Hydroxocobalamin is preferred for this type of treatment because it is highly protein bound and remains longer in circulation
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Parenteral B12 therapy
-rapid hematological response |
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What type of treatment/administeration is nascobol?
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intranasal cyanocobalamin
-maintencance of B12 defic. disease AFTER controlled by oral or parenteral means |
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Which deficiency?
Altered bibratory and position sense, memory loss, ataia, swelling of myeloid neurons, demyelination, neural cell death, paresthesia, confusion, and loss of vision coordination |
B12 deficiency
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Given to pregnant women as prophylaxis to prevent neural tube defects in the fetus
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Folic acid supplements
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Can cause ?
-Drugs like methotrexate, trimethoprin -Alcoholism -hemolytic anemia -malignancy |
Folic acid deficiency due to increased demand
-Methotrexate and trimethoprin n are dihydrofolate reductase blocking drugs |
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Mainstay in the management of anemia associated with chronic renal failure
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EPO (epoetin)
-requires adequate iron, folic acid, and vitamin B12 |
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EPO is a glycosylated protein produce by the kidneys, which regulates erythrocyte production by stimulating:
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Marrow progenitors
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Administrating of this drug is effective in treating Anemias of renal failure, AIDS, and Chronic dieseases
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Recombinant human EPO
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Why is EPO not indicated for patients needing immediate correction of severe anemia?
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Need to establlish proper iron, folate, and B12 for EPO to work
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Adverse effects of?
Hypertension Possible thrombosis Seizures in patients with Pre-existing conditions Iron deficiency |
EPO
-Elevated diastolic pressure, increase in peripheral vascular resistance |
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-Made by endothelial cells, fibroblasts
-Stimulate production of granulocytes -White blood cell deficiency |
Colony stimulating factors
-White blood cell deficiency |
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Used in the short-term treatment of patients with primary bone marrow deficiencies (following cancer chemotherapy or bone marrow transplantation)
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Granulocyte CSF
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-Increase total neutrophil counts
-Decreases neutropenia -Given SubQ or IV |
Granulocyte CSF
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