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55 Cards in this Set

  • Front
  • Back

Methotrexate

Anti metabolite - purine and thymidylate

Leflunomide

Inhibit dihydrooroatw dehydrogenase - pyrimidine


Sulfasazine

Reducw IL 2/1 and chemokines

Hydroxy chloroquine

Inhibits tlr9 - inhibits inflammation

Infliximab

Inhibit tnf alpha

Tocilizumab

Inhibition of IL 6

Rituximab

Inhibits b cells, binds to cd20

Abatacept

Inhibits cd80/86 on APC

Irinotecan

Sn-38 prodrug

Doxorubicin

Topii intercalators breaks more dsdna

5fu

Anti metabolite fdump fdutp futp DNA and RNA damage

Carpectibane

Metabolised to 5fu

Gemcitabine

Analogue of cytidine

Pacli/docetaxel

Prevents microtubule disassembly

Gefinitib

Egfr tyrosine kinase inhibitor lung cancer need mutation

Cetuximab

Egfr her1/erbb1

Bevacizumab

Vegf

Vemurafenib

Inhibits atp site of active braf kinase

Ipilimumab

Clta4 inhib/blocks cd28

Nivolumab/pembrolizumab

Pd1 inhibitor

Tamoxifen

Estrogen antagonist

Trastuzumab

Her2 inhibition of dimerisation

Abirateron

Cyp17 inhib adt

Finasteride

5alpha reductase inhib adt

Bicalutamide

Androgen receptor antagonist adt

Afibercept

Vegf rcpetor, decoy crpc

Cabozantinib

Blocks met pathway crpc kin inhib

Dasatinib

SRC tyrosine kinase inhibitor

Zoledronic acid

Decrease bone metastasis

Erlontinib

Anti egfr tki mutation needed

Aspirin

Inhibits co mi

Clopidogrel

Glycoprotein inhib iib/a - ADP p2y12 antagonist - anti coagulation mi

Tirofiban/eptifibatide

Glycoprotein iib/a receptor antagonist - prevent fibrinogen bind - anti coagulation mi

Epoprostenol

Synthetic pg12

Streptokinase, alteplase

Lead to activation of plasminogen to form plasmin, plasmin digests the fibrin of clot MI

Lisinopril

Achei - reduce BP and cardiac hypertrophy, get cough cough, HF

Metoprolol

B-blocker, slow HR, increase myocardial relaxation, greater filling in diastole, HF

Thiazide loop and k+ HF?

Reduce fluid and achieve euvolaemia, combine with acheis and b blocker

Digoxin

Inotropic agent, decreases na+/CA++ exchange HF, increases cardiac contractility, inhibits na k ATPase

Frusemide/bumetanide

Inhibit na/k/2cl transporter decrease water reabsorption

Hydrochlorothiazide, inapamide

Inhibit na cl co transporter

Spironolactone

Blocks aldosterone

Amiloride

Blocks na channels

Pril drugs - enalapril, perindopril, ramipril

Ace inhibitors

Sartans- iosartan, valsartan

Angiotensin II receptor antagonists HT

Dihydropyridines- amlopidine, nifedipine

Hypertension and angina - amlopidine indirect allosteric blocker, ccbs

Verapamil/diltiazem - non dihydropyridines

Ccbs Vera is a phenylalkylamine acts on heart, HT angina and cardiac arrhythmias

Statins - atorva, prava

Hmg coa reductase, prevents coversion to cholesterol and increases LDL receptors on hepatocytes in liver

Cholestyramine, colestipol and colesevelam

Bile salts sequestrants, inhibit the reabsorption of bile acids from the intestine

Ezetimibe

Inhibits bpc1l1 to inhibit intestinal absorption of dietary and biliary cholesterol

Nicotinic acid

Inhibits hepatic VLDL secretion

Fenofibrate/gemfibrozil

Reduce VLDL and TG levels by stimulating peroxisome proliferator activated receptor type alpha ppar

Dalcetrib/anacetrapib

Cholesterol lowering - cholesterylester transfer protein inhibitors

PCSK9 inhibitor - alirocumab

Promotes degradation of ldlr by preventing recycling of ldlr to cell membrane

Valsartan

AT II receptor antagonist, alternative to acheis HF