Drug Review: Antiepileptics

Front 1

Generics: Valproic acid (VPA)?

Back 1

Brand name: Depakote

Front 2

Generics: Phenobarbital

Back 2

Brand name: Luminal Sodium

Front 3

Generics: Phenytoin

Back 3

Brand name:Dilantin

Front 4

Generics: Ethosuximide

Back 4

Brand name: Zarontin

Front 5

Generics: Carbamazepine

Back 5

Brand name: Tegretol

Front 6

Generics: Felbamate

Back 6

Brand name: Felbatol

Front 7

Generics: Gabapentin

Back 7

Brand name: Neurontin

Front 8

Generics: Lamotrigine

Back 8

Brand name: Lamictal

Front 9

Generics: Levetiractam

Back 9

Brand name: Keppra

Front 10

Generics: Oxcarbazepine

Back 10

Brand name: Trileptoal

Front 11

Generic: Tiagabine

Back 11

Brand: Gabitril

Front 12

Generic: Topiramate

Back 12

Brand: Topomax

Front 13

Generic: Zonisamide

Back 13

Brand: Zonergan

Front 14

Generic: Pregablin

Back 14

Brand: Lyrica

Front 15

What are the 5 drugs used in partial seizure? (PC, LOV)

Back 15

PC, LOV
Phenytoin (Dilantin)
Carbamazepine (Tegretol)

Lamotrigine (Lamictal)
Oxcarbazepine (Trileptal)
Valproic Acid (Depakote)

Front 16

What are the 2 drugs used in Generalized/absence seizure? (V+E)

Back 16

Valproic acid
ethosuximide (Zarontin)

Front 17

What are the 2 drugs used in Generalized/myotonic seizure? (V+C)

Back 17

Valproic acid
clonazepam

Front 18

What are the 3 drugs used in Generalized/tonic-clonic seizure? (V+P+Cbz)

Back 18

Valproic acid
Phenytoin (Dilantin)
Carbamazepam (Tegretol))

Front 19

MOA: voltage gated sodium channel?

Back 19

Carbamazepam (Tegretol)

Front 20

MOA: inhibit NADHP aldehyde reductase and sodium/potassium ATPase system

Back 20

ethosuximide (Zarontin)

Front 21

MOA: inhibit glycine receptor on N-methyl-D-aspart(NDMA) receptor

Back 21

Drug: Felbamate (Felbatol)

Front 22

MOA: Gaba agonist, but binds to carrier protein and acts at a unique receptor

Back 22

Drug: Gabapentin

Front 23

MOA: Block neuronal sodium channel, both voltage and use dependent

Back 23

Drug: Lamotrigin (Lamictal)

Front 24

MOA: binds on a presynaptic site, Decrease high voltage activated Ca currents and delayed K current

Back 24

Drug: Levetiracetam (Keppra)

Front 25

MOA: Block voltage sensitive sodium channels and increase potassium conductivity

Back 25

Drug: Oxcarbazepin

Front 26

MOA: decrease postsynaptic excitation to elevate seizure threshold

Back 26

Drug: Phenobarbital

Front 27

MOA: Changes ion fluxes associated with depolarization repolarization and membrane stability

Back 27

Drug: Phenytoin

Front 28

MOA: a potent inhibitor of GABA uptake to prevent its removal for the synaptic space

Back 28

Drug: Tiagabine (Gabitril)

Front 29

MOA: Works on voltage-dependent sodium channels, GABA receptors and glutamate receptors.

Back 29

Drug: Topiramate (Topomax)

Front 30

MOA: increasing GABA, stimulate GABA responses and affect potassium channels

Back 30

Drug: Valproic acid

Front 31

#Q: Which of the following antiepileptics is considered to be broad spectrum in tx?

Back 31

Valproic Acid

Front 32

MOA: block voltrage sensitive sodium channels and calcium channels to decrease repetitive neuronal firing

PK: has very long t1/2
#Sulfur drug/allergy

Back 32

Zonisamide

Front 33

MOA: inhibits neurotransmitter release by binding to voltage calcium channels within the CNS

Indication: adjunct for partial seizure, and diabetic peripheral neuropathy

Back 33

Pregabalin (Lyrica)

Front 34

#Q: Newest AED on the market?

Back 34

Lyrica (Pregabalin)

Front 35

The drug to treat all generalized seizure?

Back 35

Valproic Acid

Front 36

Which drug is an autoinduction, highly lipophilic and binds to alpha-acid glycoprotein and albumin?

Back 36

Carbamazepine (Tegretol)

Front 37

Which drug ADR includes rash, leukopenia and has a active metabolite?

Back 37

Carbamazepine (Tegretol)

Front 38

Which two drugs metabolized by hydroxylation?

Back 38

Ethosuxmide
Felbamate

Front 39

Which drug metabolized in the liver, and has ADR including Diplopia and steven johnson syndrome?

Back 39

Lamotrigine (Lamictal)

Front 40

Which AED can cause coordination difficulties?

Back 40

Levetriacetam

Front 41

which drug is a prodrug that converts to 10-monohydrate derivative (MHD) and used for partial seizure in adult and children 4 yo?

Back 41

Oxcarbazepine (Trileptol)

Front 42

#Q: which is the 1st line drug for status epilepticus?

Back 42

Phenytoin

Front 43

What's the DOC for neonatal seizure?

Back 43

Phenobarbital

Front 44

Which drug has PK of Michaelis-Mention PK and ADR includes gingival hyperplasis, and rash (steven-johnson syndrome)?

Back 44

Phenytoin

Front 45

Which AED can cause Wt gain?

Back 45

Valproic acid

Front 46

Which AED can cause Wt loss?

Back 46

Felbamate