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46 Cards in this Set
- Front
- Back
Generics: Valproic acid (VPA)?
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Brand name: Depakote
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Generics: Phenobarbital
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Brand name: Luminal Sodium
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Generics: Phenytoin
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Brand name:Dilantin
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Generics: Ethosuximide
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Brand name: Zarontin
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Generics: Carbamazepine
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Brand name: Tegretol
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Generics: Felbamate
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Brand name: Felbatol
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Generics: Gabapentin
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Brand name: Neurontin
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Generics: Lamotrigine
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Brand name: Lamictal
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Generics: Levetiractam
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Brand name: Keppra
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Generics: Oxcarbazepine
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Brand name: Trileptoal
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Generic: Tiagabine
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Brand: Gabitril
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Generic: Topiramate
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Brand: Topomax
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Generic: Zonisamide
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Brand: Zonergan
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Generic: Pregablin
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Brand: Lyrica
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What are the 5 drugs used in partial seizure? (PC, LOV)
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PC, LOV
Phenytoin (Dilantin) Carbamazepine (Tegretol) Lamotrigine (Lamictal) Oxcarbazepine (Trileptal) Valproic Acid (Depakote) |
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What are the 2 drugs used in Generalized/absence seizure? (V+E)
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Valproic acid
ethosuximide (Zarontin) |
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What are the 2 drugs used in Generalized/myotonic seizure? (V+C)
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Valproic acid
clonazepam |
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What are the 3 drugs used in Generalized/tonic-clonic seizure? (V+P+Cbz)
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Valproic acid
Phenytoin (Dilantin) Carbamazepam (Tegretol)) |
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MOA: voltage gated sodium channel?
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Carbamazepam (Tegretol)
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MOA: inhibit NADHP aldehyde reductase and sodium/potassium ATPase system
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ethosuximide (Zarontin)
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MOA: inhibit glycine receptor on N-methyl-D-aspart(NDMA) receptor
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Drug: Felbamate (Felbatol)
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MOA: Gaba agonist, but binds to carrier protein and acts at a unique receptor
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Drug: Gabapentin
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MOA: Block neuronal sodium channel, both voltage and use dependent
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Drug: Lamotrigin (Lamictal)
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MOA: binds on a presynaptic site, Decrease high voltage activated Ca currents and delayed K current
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Drug: Levetiracetam (Keppra)
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MOA: Block voltage sensitive sodium channels and increase potassium conductivity
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Drug: Oxcarbazepin
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MOA: decrease postsynaptic excitation to elevate seizure threshold
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Drug: Phenobarbital
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MOA: Changes ion fluxes associated with depolarization repolarization and membrane stability
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Drug: Phenytoin
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MOA: a potent inhibitor of GABA uptake to prevent its removal for the synaptic space
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Drug: Tiagabine (Gabitril)
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MOA: Works on voltage-dependent sodium channels, GABA receptors and glutamate receptors.
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Drug: Topiramate (Topomax)
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MOA: increasing GABA, stimulate GABA responses and affect potassium channels
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Drug: Valproic acid
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#Q: Which of the following antiepileptics is considered to be broad spectrum in tx?
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Valproic Acid
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MOA: block voltrage sensitive sodium channels and calcium channels to decrease repetitive neuronal firing
PK: has very long t1/2 #Sulfur drug/allergy |
Zonisamide
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MOA: inhibits neurotransmitter release by binding to voltage calcium channels within the CNS
Indication: adjunct for partial seizure, and diabetic peripheral neuropathy |
Pregabalin (Lyrica)
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#Q: Newest AED on the market?
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Lyrica (Pregabalin)
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The drug to treat all generalized seizure?
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Valproic Acid
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Which drug is an autoinduction, highly lipophilic and binds to alpha-acid glycoprotein and albumin?
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Carbamazepine (Tegretol)
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Which drug ADR includes rash, leukopenia and has a active metabolite?
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Carbamazepine (Tegretol)
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Which two drugs metabolized by hydroxylation?
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Ethosuxmide
Felbamate |
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Which drug metabolized in the liver, and has ADR including Diplopia and steven johnson syndrome?
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Lamotrigine (Lamictal)
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Which AED can cause coordination difficulties?
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Levetriacetam
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which drug is a prodrug that converts to 10-monohydrate derivative (MHD) and used for partial seizure in adult and children 4 yo?
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Oxcarbazepine (Trileptol)
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#Q: which is the 1st line drug for status epilepticus?
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Phenytoin
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What's the DOC for neonatal seizure?
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Phenobarbital
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Which drug has PK of Michaelis-Mention PK and ADR includes gingival hyperplasis, and rash (steven-johnson syndrome)?
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Phenytoin
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Which AED can cause Wt gain?
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Valproic acid
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Which AED can cause Wt loss?
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Felbamate
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