Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
hydrophilic drug metabolism
|
drug --> kidney --> urine
|
|
|
hydrophobic drug metabolism
|
drug --> liver --> hydrophilic metabolite --> kidney --> urine
|
|
|
esters (local anesthetic) metabolism
|
hydrolyzed by esterase in blood
|
|
|
location of cytochrome P450 system
|
smooth ER of hepatocytes
|
|
|
hydrophobic drug two stage metabolism
|
phase I: oxidation/reduction to make more polar
phase II: conjugation reactions to make more polar |
|
|
cytochrome P450 enzymes
|
non-specific substrates
bind lipid soluble compds more easily CYP3a in intestinal mucosa metabolizes some drugs |
|
|
dilantin (anticonvulsive)
|
upregulates CYP 450 causing metabolism of warfarin
|
|
|
allopurinol + mercaptopurine
|
prevents mercaptopurine metabolism
|
|
|
factors that influence drug metabolism
|
liver disease (cirrhosis, hepatitis) red metabolism
cardiac disease reduces blood perfusion to liver malignant hyperthermia (triggered anesthetics) |
