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9 Cards in this Set
- Front
- Back
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Classical Cross-Resistance
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a single resistance mechanism confers resistance to a single class of antimicrobials.
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How can cross-resistance between 2 or more classes of antimicrobials occur?
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1. overlapping targets
2. active efflux - This energy-dependent export system confers low-level resistance to a wide variety of antimicrobials |
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What is microbial co-resistance?
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Results from the presence of several resistance mechanisms, in the same strain, each conferring resistance to a given class of antimicrobials. Interestingly, the corresponding resistance genes are often adjacent (physically linked) and express in a coordinated fashion. Because of the co-expression of the various genes, the use of any antibiotic that is a substrate for one of the resistance mechanisms will co-select for resistance to other classes of antimicrobials and thus for maintenance of the entire gene set.
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Inhibitors of Bacterial Cell Wall Synthesis
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B-Lactams
Vancomycin Cycloserine Bacitracin Fosfomycin Dalbavancin Telavancin |
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Inhibitors of Protein Synthesis
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Tetracyclines
Aminoglycosides Macrolides Lincosamides Chloramphenicol Streptogramins Linezolid Pleuromutilins (Retapamulin) |
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Inhibitors of Nucleic Acid Synthesis
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Quinolones
Rifamycins |
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Disruptors of Cell Membrane Permeability
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Polypeptides
Cyclic lipopeptides |
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Antifolates
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Sulfonamides
Trimethoprim |
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6 Classes of Antibiotics/Antibacterial Agents
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1. Inhibitors of Bacterial Cell Wall Synthesis
2. Inhibitors of Protein Synthesis 3. Inhibitors of Nucleic Acid Synthesis 4. Disruptors of Cell Membrane Permeability 5. Antifolates 6. Antituberculosis Agents |
