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7 Cards in this Set
- Front
- Back
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quinolones
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class of antibiotics that block DNA synthesis by targeting DNA gyrase and topoisomerase IV
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beta-lactam antibiotics - name mechanism, how resistance forms, examples.
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Inhibit transpeptidase by covalently modifying it, preventing polymer formation.
Resistance arises by hydrolysis by beta-lactamases. These include penicillins, monobactams, cephalosporins, carbapenem. |
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Ciavulanic acid
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Beta-lactamase inhibitor, can be given with beta-lactam antibiotics to slow resistance
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phosphomycin
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analog of phosphoenolpyruvate, inhibits enolpyruvyl transeferase which maeks up UDP-GlcNAc into UDP-MurNAc
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cycloserine
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resembles D-alanine, inhibits alanine, racemase (which makes D-alanine), also inhibits D-ala synthetase.
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vancomycin
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binds D-ala end of peptidoglycan pentapeptide, preventing release from carrier and subsequent elongation.
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bacitracin
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complexes with membrane transporter and prevents its activation
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