Drug List 1: Moa [Pharmacology I]

Front 1

Mechanism of Action for Botulinum Toxin (bott' you lye num)

Back 1

Blocks the release of ACh at presynaptic nerve terminal binding sites

Front 2

Mechanism of Action for Methyldopa (meth ill doe' pa)

Back 2

Inhibits aromatic L-amino acid decarboxylase, which is the enzyme responsible for converting DOPA to dopamine. Its metabolite, methylnorepinephrine, acts presynaptically as an alpha2-receptor agonist.

Front 3

Mechanism of Action for Darifenacin (dar ee fen' a sin)

Back 3

M3 - receptor antagonist

Front 4

Mechanism of Action for Phenylephrine (fen il ef' rin)

Back 4

Selective alpha1 - receptor agonist

Front 5

Mechanism of Action for Clonidine (kloe' ni deen)

Back 5

Selective alpha2 - receptor agonist

Front 6

Mechanism of Action for Dobutamine (doe byoo' ta meen)

Back 6

Selective beta1 - receptor agonist (also activates alpha1 - receptors) used in the treatment of heart failure and cardiogenic shock.

Front 7

Mechanism of Action for Terbutaline (ter byoo' ta leen)

Back 7

Selective beta2 - receptor agonist

Front 8

Mechanism of Action for Metoprolol (me toe' proe lole)

Back 8

Selective beta1 - receptor antagonist

Front 9

Mechanism of Action for Atenolol (a ten' oh lole)

Back 9

Selective beta1 - receptor antagonist

Front 10

Mechanism of Action for Prazosin (pra' zoe sin)

Back 10

Historically described as a selective, reversible, alpha1 - receptor antagonist (recently found to antagonize alpha2b - and alpha2c w/ a 30-fold higher affinity than alpha2a)

Front 11

Mechanism of Action for Imipramine (im ip'ra meen)

Back 11

Interfers w/ NET at adrenergic synapses in the CNS, leading to an accumulation of NE at the receptors

Front 12

Mechanism of Action for Entacopone (en ta' ka pone)

Back 12

Peripherally inhibits catechol-O-methyltransferase (COMT)

Front 13

Mechanism of Action for Tolcapone (tole' ka pone)

Back 13

Catechol-O-methyltransferase (COMT) inhibitor capable of crossing the BBB

Front 14

Mechanism of Action for Tranylcypromine (trans il sip' roe meen)

Back 14

Tranylcypromine, like isocarboxazid & phenelzine, nonselectively and irreversibly inhibits both MAO-A & MAO-B, thereby increasing catecholamine levels by blocking catecholamine degradation.

Front 15

Mechanism of Action for Reserpine (re ser' peen)

Back 15

Irreversibly damages vesicular monoamine transporters (VMAT-1 & VMAT-2) that concentrate NE, serotonin, & dopamine in vesicles, thus leading to their depletion in adrenergic terminals via intraneuronal, mitochondrial MAO metabolism.

Front 16

Mechanism of Action for Propranolol (proe pran' oh lole)

Back 16

Selective beta - receptor antagonist (Beta3 is relatively resistant)

Front 17

Mechanism of Action for Phenoxybenzamine (fen ox ee ben' za meen)

Back 17

Phenoxybenzamine irreversibly blocks both alpha1 & alpha2 receptors (alpha1 > alpha2).

Front 18

Mechanism of Action for Selegiline (se le' ji leen)

Back 18

Selective, irreversible MAO-B inhibitor

Front 19

Mechanism of Action for Phenelzine (fen' el zeen)

Back 19

Phenelzine, like inocarboxazid & tranylcypromine, non-selectively and irreversibly inhibits both MAO-A and MAO-B, thereby increasing catecholamine levels by blocking catecholamine degradation.

Front 20

Mechanism of Action for Isocarboxazid (eye soe kar box' azid)

Back 20

Isocarboxazid, like phenylzine & tranylcypromine, non-selectively and irreversibly inhibits both MAO-A and MAO-B, thereby increasing catecholamine levels by blocking catecholamine degradation.