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30 Cards in this Set
- Front
- Back
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fluoxetine, sertraline, or quinidine + codeine
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decreased codeine effectiveness
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quinidine, amiodarone, verapamil + digoxin
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increases digoxin levels by 25-100%
bradycardia |
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lovastatin, atorvastatin, nifedipine + grapefruit juice
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increased levels of lovastatin, atorvastatin, and nifedipine
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St. John's wort, rifampin + cyclosporine
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decreases levels of cyclosporine
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erythromycin, ketoconazole, diltiazem + cyclosporine
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increased levels of cyclosporine
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warfarin + miconazole vaginal cream
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increased effects of warfarin (anticoagulation)
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diltiazem, verapamil + propranolol
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increased (additive) effects of propranolol; excessive bradycardia
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erythromycin, ciprofloxacin + theophylline
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increases theophylline conc.
decreases erythromycin conc. |
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albuterol + propranolol
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decreases bronchodilation (decreased effectiveness of albuterol)
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NTG, isosorbide dinitrate + sildenafil(Viagra)
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additive hypotension, b/c excessive dilation
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Mg2+, Fe2+, Ca2+, Zn2+, Al3+ + ciprofloxacin
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decreases bioavailability of cipro
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oral contraceptives + antibiotics
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decreased effectiveness of oc (use backup!)
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SMX-TMP(Bactrim), NSAIDs, ASA + methotrexate
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increases methotrexate conc.
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oral contraceptives + smoking
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increased CV risk (stroke, MI, blood clots) in women over 35
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warfarin + rifampin
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decreased warfarin effectiveness
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cimetidine, Bactrim, oxandrolone, amiodarone + warfarin
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increased risk of bleeding (increased anticoagulation effects of warfarin)
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NSAIDs, ASA + warfarin
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increased risk of bleeding (increased anticoagulation)
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NSAIDs + furosemide(Lasix)
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decreased diuretic effects (decreased effectiveness of furosemide)
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rifampin, St John's wort + nelfinavir, indinavir, ritonavir
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decreases antiretroviral protease inhibitors levels, decreases their effectiveness and increasing chances of resistance
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caffeine + ciprofloxacin
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increases caffeine levels and effects
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tricyclic antidepressants + clonidine
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inhibits clonidine's antihypertensive effects
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imipramine(tricyclic antidepressant) +
epinephrine |
excessive increase in bp
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azathioprine, 6-mercaptopurine + allopurinol
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increases toxicity of azathioprine by increasing it's bioavailability
(azathioprine ---> 6-MP) |
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itraconazole, gemfibrozil + simvastatin, lovastatin
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reduced metabolism of statins
increased myopathy |
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cholestyramine, colestipol + pravastatin, fluvastatin
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reduced absorption of statins
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MAOIs + SSRIs
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serotonin syndrome (dysfunction of CNS, autonomic and neuromuscular systems)
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MAOIs + pseudoephedrine
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severe hypertension
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ACE inhibitors(captopril), spironolactone + potassium
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increased levels of K
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Ca2+, raloxifene(Evista) + thyroid hormone
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reduced absorption of the thyroid hormone
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lithium + NaCl
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lithium levels change inversely proportional to Na levels
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